GSN (gelsolin)

2003-08-01  

Identity

HGNC
GSN
LOCATION
9q33.2
LOCUSID
2934
ALIAS
ADF,AGEL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2934
MIM: 137350
HGNC: 4620
Ensembl: ENSG00000148180

Variants:

dbSNP: 2934
ClinVar: 2934
TCGA: ENSG00000148180
COSMIC: GSN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148180ENST00000373806Q5T0H8
ENSG00000148180ENST00000373808P06396
ENSG00000148180ENST00000373818P06396
ENSG00000148180ENST00000373818A0A384MEF1
ENSG00000148180ENST00000373823P06396
ENSG00000148180ENST00000394353A0A0A0MS51
ENSG00000148180ENST00000432226Q5T0I0
ENSG00000148180ENST00000449733A0A0A0MT01
ENSG00000148180ENST00000477104A0A0U1RQL8
ENSG00000148180ENST00000545652P06396

Expression (GTEx)

0
500
1000
1500
2000
2500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382169512024The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.1
383733912024Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.0
382169512024The regulation of plasma gelsolin by DNA methylation in ovarian cancer chemo-resistance.1
383733912024Proteomic Analysis Identifies GSN as a Noninvasive Circulating Serum Biomarker for Predicting Early Recurrence of Hepatocellular Carcinoma.0
366023072023HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.2
366500382023GSN gene frameshift mutations in Alzheimer's disease.4
368810742023Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.1
369671052023Role and therapeutic potential of gelsolin in atherosclerosis.3
371204542023mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.2
379587472023Gelsolin, an Actin-Binding Protein: Bioinformatic Analysis and Functional Significance in Urothelial Bladder Carcinoma.0
366023072023HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.2
366500382023GSN gene frameshift mutations in Alzheimer's disease.4
368810742023Fusion of the High-mobility Group AT-Hook 2 (HMGA2) and the Gelsolin (GSN) Genes in Lipomas With t(9;12)(q33;q14) Chromosomal Translocation.1
369671052023Role and therapeutic potential of gelsolin in atherosclerosis.3
371204542023mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.2

Citation

Dessen P

GSN (gelsolin)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/206/teaching-explorer/meetings/js/gene-fusions/?id=206