BMF (Bcl2 modifying factor)

2003-02-01  

Identity

HGNC
BMF
LOCATION
15q15.1
LOCUSID
90427
ALIAS
-

Other Information

Locus ID:

NCBI: 90427
MIM: 606266
HGNC: 24132
Ensembl: ENSG00000104081

Variants:

dbSNP: 90427
ClinVar: 90427
TCGA: ENSG00000104081
COSMIC: BMF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104081ENST00000354670Q96LC9
ENSG00000104081ENST00000397573Q96LC9
ENSG00000104081ENST00000431415Q96LC9
ENSG00000104081ENST00000557870H0YNT3
ENSG00000104081ENST00000558774Q96LC9
ENSG00000104081ENST00000559701Q96LC9
ENSG00000104081ENST00000560430H0YK50
ENSG00000104081ENST00000561282Q96LC9
ENSG00000104081ENST00000561360Q96LC9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BMF and translocation to mitochondriaREACTOMER-HSA-139910
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersREACTOMER-HSA-111453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
331492652021The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival.14
336580122021FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2.58
331492652021The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival.14
336580122021FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2.58
326208492020Characterization of an alternative BAK-binding site for BH3 peptides.14
326208492020Characterization of an alternative BAK-binding site for BH3 peptides.14
275246132016Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.34
275399592016Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.16
278994422016Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.35
275246132016Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.34
275399592016Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.16
278994422016Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.35
261812062015Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).52
261812062015Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).52
249010462014Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.20

Citation

Dessen P

BMF (Bcl2 modifying factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/242/cancer-prone-explorer/meetings/