NFIB (nuclear factor I B)

2003-02-01  

Identity

HGNC
NFIB
LOCATION
9p23
LOCUSID
4781
ALIAS
CTF,HMGIC/NFIB,MACID,NF-I/B,NF1-B,NFI-B,NFI-RED,NFIB2,NFIB3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4781
MIM: 600728
HGNC: 7785
Ensembl: ENSG00000147862

Variants:

dbSNP: 4781
ClinVar: 4781
TCGA: ENSG00000147862
COSMIC: NFIB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147862ENST00000380921Q5W0Y9
ENSG00000147862ENST00000380924Q5VW31
ENSG00000147862ENST00000380934A0A0A0MRX8
ENSG00000147862ENST00000380953O00712
ENSG00000147862ENST00000380959O00712
ENSG00000147862ENST00000380959Q5VW28
ENSG00000147862ENST00000397575Q5VW30
ENSG00000147862ENST00000397579Q5VW27
ENSG00000147862ENST00000397581Q5VW26
ENSG00000147862ENST00000493697U3KPY9
ENSG00000147862ENST00000543693O00712
ENSG00000147862ENST00000606230U3KQE8
ENSG00000147862ENST00000622520A0A087WXP2
ENSG00000147862ENST00000635877A0A1B0GWI9
ENSG00000147862ENST00000636057A0A1B0GW37
ENSG00000147862ENST00000636063A0A1B0GTC1
ENSG00000147862ENST00000636432A0A1B0GVN4
ENSG00000147862ENST00000636735A0A1B0GWB8
ENSG00000147862ENST00000637640A0A1B0GU97
ENSG00000147862ENST00000637742A0A1B0GWJ4
ENSG00000147862ENST00000646622A0A2R8Y7V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotation, VariantAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotation, VariantAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
383859862024Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.1
383859862024Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.1
361523082023Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.1
363698832023Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.6
367306372023Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.5
367568552023Marked intrafamilial variability of clinical and neuroimaging manifestations in NFIB-related developmental disorder.0
374054272023CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.0
376048292023NFIB facilitates replication licensing by acting as a genome organizer.0
361523082023Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.1
363698832023Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.6
367306372023Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.5
367568552023Marked intrafamilial variability of clinical and neuroimaging manifestations in NFIB-related developmental disorder.0
374054272023CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.0
376048292023NFIB facilitates replication licensing by acting as a genome organizer.0
349697592022Nuclear Factor IA Is Down-regulated in Muscle-invasive and High-grade Bladder Cancers.3

Citation

Dessen P

NFIB (nuclear factor I B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/253/gene-fusions/meetings/hgnc