TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

2000-09-01 Jean-Loup Huret Affiliation

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC

TAF15

LOCATION

17q12

LOCUSID

8148

ALIAS

Npl3,RBP56,TAF2N,TAFII68

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

spans 37kb; 16 exons

Transcription

2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp

Proteins

Description

589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term

Expression

wide; in the fetus and in the adult

Localisation

nuclear

Function

single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription

Homology

with EWSR1 and FUS

Mutations

Somatic

overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation

Implicated in

Entity name

extraskeletal myxoid chondrosarcomas with t(9;17)(q22;q11) --> 5 prime TAF15 3 prime TEC

Disease

a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities

Breakpoints

Bibliography

Pubmed ID	Last Year	Title	Authors
10637511	1999	The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.	Bertolotti A et al
10664584	2000	TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes.	Green MR et al
9795213	1998	Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.	Morohoshi F et al
10602519	1999	Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).	Panagopoulos I et al
7935765	1994	Yeast TAFIIS in a multisubunit complex required for activated transcription.	Reese JC et al
10537274	1999	Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.	Sjögren H et al

Other Information

Locus ID:

NCBI: 8148
MIM: 601574
HGNC: 11547
Ensembl: ENSG00000270647

Variants:

dbSNP: 8148
ClinVar: 8148
TCGA: ENSG00000270647
COSMIC: TAF15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000270647	ENST00000603393	A0A075B7E4
ENSG00000270647	ENST00000603427	A0A075B7D6
ENSG00000270647	ENST00000603777	A0A075B7D9
ENSG00000270647	ENST00000603967	A0A075B7C1
ENSG00000270647	ENST00000604694	A0A075B7F4
ENSG00000270647	ENST00000604841	Q92804
ENSG00000270647	ENST00000604879	A0A075B7F2
ENSG00000270647	ENST00000605844	Q92804

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Basal transcription factors	KEGG	ko03022
Basal transcription factors	KEGG	hsa03022
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38057661	2024	TAF15 amyloid filaments in frontotemporal lobar degeneration.	5
38226841	2024	circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.	2
38811189	2024	circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.	0
38057661	2024	TAF15 amyloid filaments in frontotemporal lobar degeneration.	5
38226841	2024	circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.	2
38811189	2024	circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.	0
36895010	2023	CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.	7
37037864	2023	TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.	2
37257820	2023	m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.	6
36895010	2023	CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.	7
37037864	2023	TAF15 promotes cell proliferation, migration and invasion of gastric cancer via activation of the RAF1/MEK/ERK signalling pathway.	2
37257820	2023	m6A-enriched lncRNA LINC00839 promotes tumor progression by enhancing TAF15-mediated transcription of amine oxidase AOC1 in nasopharyngeal carcinoma.	6
35228660	2022	LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.	11
35643629	2022	The SGYS motif of TAF15 prion-like domain is critical to amyloid fibril formation.	2
35228660	2022	LncRNA LINC00649 recruits TAF15 and enhances MAPK6 expression to promote the development of lung squamous cell carcinoma via activating MAPK signaling pathway.	11

Citation

Jean-Loup Huret

TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

Atlas Genet Cytogenet Oncol Haematol. 2000-09-01

Online version: http://atlasgeneticsoncology.org/gene/256/favicon/case-report-explorer/cancer-prone-explorer/