RAP1B (RAP1B, member of RAS oncogene family)

2001-05-01   Jean de Gunzburg  

Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France

Identity

HGNC
RAP1B
LOCATION
12q15
LOCUSID
5908
ALIAS
K-REV,RAL1B
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image

Description

The gene emcompasses 7 codinng exons covering 10779 bp on chromosome 12

Proteins

Expression

ubiquitous ; highest in platelets and neutrophils

Localisation

Rap1 is bound to membranes. In many cell types, it is found in a perinuclear compartment overlapping the Golgi. Rap1 proteins (A and B) are phosphorylated near the C-ter by cAMP-dependent protein kinase. This results in translocation of part of the Rap1 pool to the cytosol.

Function

The function of Rap1 is still a matter of debate. Its overexpression is able to compete with the activation of Raf-1 by active Ras. Active Rap1B has been shown to activate the B-Raf kinase and the MEK-ERK cascade. In several cellular models, Rap1 has been shown to be involved in the regulation of integrin-mediated cell adhesion.

Homology

98% identical to Rap1A, 60% identical to Rap2 , 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity name
no implication in pathologies characterized so far

Article Bibliography

Pubmed IDLast YearTitleAuthors
113319112001Rap1 signalling: adhering to new models.Bos JL et al

Other Information

Locus ID:

NCBI: 5908
MIM: 179530
HGNC: 9857
Ensembl: ENSG00000127314

Variants:

dbSNP: 5908
ClinVar: 5908
TCGA: ENSG00000127314
COSMIC: RAP1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127314ENST00000250559P61224
ENSG00000127314ENST00000250559A0A024RB87
ENSG00000127314ENST00000341355P61224
ENSG00000127314ENST00000341355A0A024RB87
ENSG00000127314ENST00000378985B7ZB78
ENSG00000127314ENST00000393436P61224
ENSG00000127314ENST00000393436A0A024RB87
ENSG00000127314ENST00000422358F8WBC0
ENSG00000127314ENST00000425247E7ESV4
ENSG00000127314ENST00000450214P61224
ENSG00000127314ENST00000453560F5H004
ENSG00000127314ENST00000485252F5H4H0
ENSG00000127314ENST00000489473F5H0S2
ENSG00000127314ENST00000534899F5GWU8
ENSG00000127314ENST00000535492F5H823
ENSG00000127314ENST00000537460P61224
ENSG00000127314ENST00000537460A0A024RB87
ENSG00000127314ENST00000538283F5H500
ENSG00000127314ENST00000538877F5GYH7
ENSG00000127314ENST00000538980F5GZG1
ENSG00000127314ENST00000539091P61224
ENSG00000127314ENST00000540209P61224
ENSG00000127314ENST00000540781F5GX62
ENSG00000127314ENST00000541167F5H491
ENSG00000127314ENST00000541216F5H7Y6
ENSG00000127314ENST00000541386F5H0S2
ENSG00000127314ENST00000542018F5H0B7
ENSG00000127314ENST00000542145P61224
ENSG00000127314ENST00000543393B7ZB78
ENSG00000127314ENST00000543697F5GYB5
ENSG00000127314ENST00000545270F5H6R7
ENSG00000127314ENST00000545720F5H077

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Focal adhesionKEGGko04510
Leukocyte transendothelial migrationKEGGko04670
Long-term potentiationKEGGko04720
Renal cell carcinomaKEGGko05211
MAPK signaling pathwayKEGGhsa04010
Focal adhesionKEGGhsa04510
Leukocyte transendothelial migrationKEGGhsa04670
Long-term potentiationKEGGhsa04720
Renal cell carcinomaKEGGhsa05211
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Platelet activationKEGGhsa04611
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Rap1 signallingREACTOMER-HSA-392517
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
MAP2K and MAPK activationREACTOMER-HSA-5674135
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Integrin alphaIIb beta3 signalingREACTOMER-HSA-354192
GRB2:SOS provides linkage to MAPK signaling for IntegrinsREACTOMER-HSA-354194
p130Cas linkage to MAPK signaling for integrinsREACTOMER-HSA-372708
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
RET signalingREACTOMER-HSA-8853659
Neutrophil degranulationREACTOMER-HSA-6798695
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by RAS mutantsREACTOMER-HSA-6802949
Signaling by high-kinase activity BRAF mutantsREACTOMER-HSA-6802948
Signaling by moderate kinase activity BRAF mutantsREACTOMER-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAFREACTOMER-HSA-6802955
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates RAP1 and RAC1REACTOMER-HSA-8875555

References

Pubmed IDYearTitleCitations
378503572024Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia.0
378503572024Adding to the evidence of gene-disease association of RAP1B and syndromic thrombocytopenia.0
369514842023Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.3
375151452023ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.0
369514842023Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.3
375151452023ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.0
360566902022SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.9
360566902022SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP.9
343069972021LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p.7
343069972021LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p.7
317381482020MiR-181a Reduces Platelet Activation via the Inhibition of Endogenous RAP1B.6
318773032020miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-κB/Twist1 pathway.10
321129032020MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b.13
321843892020Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.30
321914972020Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B.8

Citation

Jean de Gunzburg

RAP1B (RAP1B, member of RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2001-05-01

Online version: http://atlasgeneticsoncology.org/gene/273/gene-fusions/case-report-explorer/hgnc