RAP2B (RAP2B, member of RAS oncogene family)

2001-05-01   Jean de Gunzburg  

Laboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France

Identity

HGNC
RAP2B
LOCATION
3q25.2
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
5912
ALIAS
-
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image

Description

The gene contains 1 coding exon only covering 644 bp

Proteins

Expression

ubiquitous ; higher in brain and hemopoietic tissues (especially rich in platelets and meutrophils)

Localisation

plasma and/or intracellular membranes (endoplasmic reticulum)

Function

unknown

Homology

90% identical to Rap2A, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity name
no implication in pathologies characterized so far

Bibliography

Pubmed IDLast YearTitleAuthors
109131892000Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.Ohba Y et al

Other Information

Locus ID:

NCBI: 5912
MIM: 179541
HGNC: 9862
Ensembl: ENSG00000181467

Variants:

dbSNP: 5912
ClinVar: 5912
TCGA: ENSG00000181467
COSMIC: RAP2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181467ENST00000323534P61225

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
369582932023Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis.0
369582932023Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis.0
364449112022MicroRNA-708 suppresses the proliferation, migration, and invasion of human retinoblastoma cells by targeting RAP2B, a member of the RAS oncogene family.0
364449112022MicroRNA-708 suppresses the proliferation, migration, and invasion of human retinoblastoma cells by targeting RAP2B, a member of the RAS oncogene family.0
330233312021Long non-coding RNA CCAT1 promotes non-small cell lung cancer progression by regulating the miR-216a-5p/RAP2B axis.4
330233312021Long non-coding RNA CCAT1 promotes non-small cell lung cancer progression by regulating the miR-216a-5p/RAP2B axis.4
307633572019The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole.5
309976392019Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma.5
307633572019The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole.5
309976392019Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma.5
283901122018Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway.10
284095472018Long Noncoding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b.36
283901122018Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway.10
284095472018Long Noncoding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b.36
280817292017Knockdown of Rap2B Inhibits the Proliferation and Invasion in Hepatocellular Carcinoma Cells.12

Citation

Jean de Gunzburg

RAP2B (RAP2B, member of RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2001-05-01

Online version: http://atlasgeneticsoncology.org/gene/275/favicon/manifest.json