FNBP1 (Formin Binding Protein 17)

2001-03-01   Uta Fuchs  , Arndt Borkhardt  

Childrens University Hospital Giessen, Hematology & Oncology, Feulgenstr. 12, 35392 Giessen, Germany

Identity

HGNC
FNBP1
LOCATION
9q34.11
LOCUSID
23048
ALIAS
FBP17
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

at least 2042 bp

Transcription

open reading frame of 679 amino acids

Proteins

Atlas Image
FCH-domain: amino terminus; cdc15 homology region: aa 96-290; Rho-binding domain: aa 475-537; SH3-domain: aa 612-669

Description

679 amino acids, 75 kDa

Expression

strong expression in epithelial cells from the respiratory system, gastrointestinal tract, urinary, and reproductive system

Localisation

exclusively cytoplasmatic

Function

interacts with Sorting nexin 2 (SNX2) in vivo and in vitro

Mutations

Germinal

unknown

Somatic

unknown

Implicated in

Entity name
t(9;11)(q34;q23) acute non lymphocytic leukemia --> FNBP1 - KMT2A
Prognosis
poor
Hybrid gene
5 MLL - 3 FBP17
Atlas Image
Fusion protein
MLL/FBP17

Article Bibliography

Pubmed IDLast YearTitleAuthors
114386822001The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.Fuchs U et al

Other Information

Locus ID:

NCBI: 23048
MIM: 606191
HGNC: 17069
Ensembl: ENSG00000187239

Variants:

dbSNP: 23048
ClinVar: 23048
TCGA: ENSG00000187239
COSMIC: FNBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187239ENST00000355681Q96RU3
ENSG00000187239ENST00000420781Q96RU3
ENSG00000187239ENST00000443566B7ZL14
ENSG00000187239ENST00000446176Q96RU3
ENSG00000187239ENST00000449089H0Y7W6

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375660432023FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.0
375660432023FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.0
349983852022Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.5
351341262022Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion.2
349983852022Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD.5
351341262022Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion.2
342026062021Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells.4
342026062021Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells.4
326656372020High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas.5
326656372020High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas.5
318628852019An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation.27
318628852019An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation.27
296516322018High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation.12
300616812018FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.48
296516322018High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation.12

Citation

Uta Fuchs ; Arndt Borkhardt

FNBP1 (Formin Binding Protein 17)

Atlas Genet Cytogenet Oncol Haematol. 2001-03-01

Online version: http://atlasgeneticsoncology.org/gene/353/gene-fusions-explorer/tumors-explorer/js/lib/zoomerang.js