MSN (moesin)

2001-08-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
MSN
LOCATION
Xq12
IMAGE
Atlas Image
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
4478
ALIAS
moesin (membrane-organising extension spike protein)
FUSION GENES
Show Gene Fusions

DNA/RNA

Transcription

3879 bp mRNA with a 1733 bp of coding sequence

Proteins

Description

576 amino acids, 75 kDa; contains in N-term a globular membrane binding domain (band 4.1 like domain (amino acids 57 to 224), known also as the four-point-one/ezrin/radixin/moesin domai, an alpha helix domain, and in C-term a domain which interact with actin filaments

Expression

wide; expressed differentially in microvilli and cell adhesion sites

Function

cytoskeleton protein; binds to the plasma membrane and interacts with actin/myosin; role in cell-cell recognition and signaling

Homology

Ezrin, radixin, moesin are called the ERM proteins; they are members ofthe band 4.1 superfamily

Implicated in

Entity name
t(X;2)(q11;p23) --> MSN - ALK
Disease
found in a case of ALK+ anaplasic large cell lymphoma
Fusion protein
1005 amino acids, 125 kDa; membrane restricted; ;448 N-term amino acid from MSN, containing the band 4.1 like domain and most of the alpha helix domain, fused to the 557 (instead of the usual 562) C-term amino acids from ALK (i.e. the cytoplasmic portion of ALK with the tyrosine kinase domain).
Oncogenesis
tyrosine kinase activity.

Article Bibliography

Pubmed IDLast YearTitleAuthors
82271931993Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells.Berryman M et al
100475171999Regulation of cortical structure by the ezrin-radixin-moesin protein family.Bretscher A et al
97578241998The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane.Chishti AH et al
19242891991Moesin: a member of the protein 4.1-talin-ezrin family of proteins.Lankes WT et al
103224531999ERM proteins in cell adhesion and membrane dynamics.Mangeat P et al
113108342001Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma.Tort F et al
105749071999Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins.Tsukita S et al

Other Information

Locus ID:

NCBI: 4478
MIM: 309845
HGNC: 7373
Ensembl: ENSG00000147065

Variants:

dbSNP: 4478
ClinVar: 4478
TCGA: ENSG00000147065
COSMIC: MSN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147065ENST00000360270P26038
ENSG00000147065ENST00000360270V9HWC0
ENSG00000147065ENST00000609672V9GZ54

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380522922024Two cases of pediatric primary immunodeficiency caused by a familial moesin(MSN)gene mutation.0
381415162024Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma.0
382679732024The role of moesin in diagnosing and assessing severity of lymphangioleiomyomatosis.0
380522922024Two cases of pediatric primary immunodeficiency caused by a familial moesin(MSN)gene mutation.0
381415162024Moesin affects the plasma membrane expression and the immune checkpoint function of CD47 in human ovarian clear cell carcinoma.0
382679732024The role of moesin in diagnosing and assessing severity of lymphangioleiomyomatosis.0
347853482022Role of moesin in the effect of glucagon-like peptide-1 on advanced glycation end products-induced endothelial barrier dysfunction.2
357189752022Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.2
361191092022Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50.3
347853482022Role of moesin in the effect of glucagon-like peptide-1 on advanced glycation end products-induced endothelial barrier dysfunction.2
357189752022Identification of Neural Progenitor Cell-associated Chemoradiotherapy Resistance Gene Set (ARL4C, MSN, TNFAIP6) for Prognosis of Glioma.2
361191092022Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50.3
336288532021Moesin Is a Novel Biomarker of Endothelial Injury in Sepsis.5
338386922021Moesin as a prognostic indicator of lung adenocarcinoma improves prognosis by enhancing immune lymphocyte infiltration.12
346037942021Activation of TMEM16A Ca(2+)-activated Cl(-) channels by ROCK1/moesin promotes breast cancer metastasis.12

Citation

Jean-Loup Huret

MSN (moesin)

Atlas Genet Cytogenet Oncol Haematol. 2001-08-01

Online version: http://atlasgeneticsoncology.org/gene/363/css/gene-fusions-explorer/hgnc