CDC14A (cell division cycle 14A)

2003-06-01 Affiliation

Identity

HGNC

CDC14A

LOCATION

1p21.2

LOCUSID

8556

ALIAS

DFNB105,DFNB32,DFNB35,cdc14,hCDC14

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8556
MIM: 603504
HGNC: 1718
Ensembl: ENSG00000079335

Variants:

dbSNP: 8556
ClinVar: 8556
TCGA: ENSG00000079335
COSMIC: CDC14A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000079335	ENST00000336454	Q9UNH5
ENSG00000079335	ENST00000361544	Q9UNH5
ENSG00000079335	ENST00000370124	Q9UNH5
ENSG00000079335	ENST00000455467	C9JSP6
ENSG00000079335	ENST00000635056	A0A0U1RQX7
ENSG00000079335	ENST00000644676	A0A2R8YDJ8
ENSG00000079335	ENST00000644813	Q9UNH5
ENSG00000079335	ENST00000644844	A0A2R8YEK7
ENSG00000079335	ENST00000646563	A0A2R8Y3W8
ENSG00000079335	ENST00000646665	A0A2R8YGM0
ENSG00000079335	ENST00000647005	A0A2R8Y6L0
ENSG00000079335	ENST00000647203	A0A2R8Y5L8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell cycle	KEGG	ko04110
Cell cycle	KEGG	hsa04110
Signal Transduction	REACTOME	R-HSA-162582
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK6/MAPK4 signaling	REACTOME	R-HSA-5687128
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Regulation of mitotic cell cycle	REACTOME	R-HSA-453276
APC/C-mediated degradation of cell cycle proteins	REACTOME	R-HSA-174143
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	REACTOME	R-HSA-176407

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33328327	2021	Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.	6
33328327	2021	Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.	6
31906439	2020	Novel Loss-of-Function Variants in CDC14A are Associated with Recessive Sensorineural Hearing Loss in Iranian and Pakistani Patients.	7
32231217	2020	When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).	1
32372016	2020	UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.	7
33090408	2020	The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.	0
31906439	2020	Novel Loss-of-Function Variants in CDC14A are Associated with Recessive Sensorineural Hearing Loss in Iranian and Pakistani Patients.	7
32231217	2020	When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).	1
32372016	2020	UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.	7
33090408	2020	The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.	0
30467237	2019	The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.	17
30467237	2019	The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.	17
29293958	2018	CDC14A phosphatase is essential for hearing and male fertility in mouse and human.	31
30089874	2018	Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1.	3
29293958	2018	CDC14A phosphatase is essential for hearing and male fertility in mouse and human.	31

Citation

Dessen P

CDC14A (cell division cycle 14A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40000/cancer-prone-explorer/meetings/haematological-explorer/