CDC14A (cell division cycle 14A)

2003-06-01  

Identity

HGNC
CDC14A
LOCATION
1p21.2
LOCUSID
8556
ALIAS
DFNB105,DFNB32,DFNB35,cdc14,hCDC14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8556
MIM: 603504
HGNC: 1718
Ensembl: ENSG00000079335

Variants:

dbSNP: 8556
ClinVar: 8556
TCGA: ENSG00000079335
COSMIC: CDC14A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079335ENST00000336454Q9UNH5
ENSG00000079335ENST00000361544Q9UNH5
ENSG00000079335ENST00000370124Q9UNH5
ENSG00000079335ENST00000455467C9JSP6
ENSG00000079335ENST00000635056A0A0U1RQX7
ENSG00000079335ENST00000644676A0A2R8YDJ8
ENSG00000079335ENST00000644813Q9UNH5
ENSG00000079335ENST00000644844A0A2R8YEK7
ENSG00000079335ENST00000646563A0A2R8Y3W8
ENSG00000079335ENST00000646665A0A2R8YGM0
ENSG00000079335ENST00000647005A0A2R8Y6L0
ENSG00000079335ENST00000647203A0A2R8Y5L8

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
333283272021Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.6
333283272021Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.6
319064392020Novel Loss-of-Function Variants in CDC14A are Associated with Recessive Sensorineural Hearing Loss in Iranian and Pakistani Patients.7
322312172020When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).1
323720162020UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.7
330904082020The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.0
319064392020Novel Loss-of-Function Variants in CDC14A are Associated with Recessive Sensorineural Hearing Loss in Iranian and Pakistani Patients.7
322312172020When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).1
323720162020UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.7
330904082020The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.0
304672372019The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.17
304672372019The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.17
292939582018CDC14A phosphatase is essential for hearing and male fertility in mouse and human.31
300898742018Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1.3
292939582018CDC14A phosphatase is essential for hearing and male fertility in mouse and human.31

Citation

Dessen P

CDC14A (cell division cycle 14A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40000/cancer-prone-explorer/teaching-explorer/humanGenome