CDC25B (cell division cycle 25B)

2003-02-01  

Identity

HGNC
CDC25B
LOCATION
20p13
LOCUSID
994
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 994
MIM: 116949
HGNC: 1726
Ensembl: ENSG00000101224

Variants:

dbSNP: 994
ClinVar: 994
TCGA: ENSG00000101224
COSMIC: CDC25B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101224ENST00000245960P30305
ENSG00000101224ENST00000340833P30305
ENSG00000101224ENST00000344256B4DIG0
ENSG00000101224ENST00000379598G8JLH2
ENSG00000101224ENST00000439880P30305

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cell cycleKEGGko04110
Progesterone-mediated oocyte maturationKEGGko04914
MAPK signaling pathwayKEGGhsa04010
Cell cycleKEGGhsa04110
Progesterone-mediated oocyte maturationKEGGhsa04914
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
DNA damage-induced cell cycle checkpointsKEGGhsa_M00691
DNA damage-induced cell cycle checkpointsKEGGM00691
DiseaseREACTOMER-HSA-1643685
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Cyclin B2 mediated eventsREACTOMER-HSA-157881
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381941582024Transcription factor E2F3 activates CDC25B to regulate DNA damage and promote mitoxantrone resistance in stomach adenocarcinoma.0
381941582024Transcription factor E2F3 activates CDC25B to regulate DNA damage and promote mitoxantrone resistance in stomach adenocarcinoma.0
366553912023Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.0
366553912023Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study.0
337459682021CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.4
344788362021Aβ monomers protect lens epithelial cells against oxidative stress by upregulating CDC25B.7
337459682021CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.4
344788362021Aβ monomers protect lens epithelial cells against oxidative stress by upregulating CDC25B.7
318564142020Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B.12
322483842020CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.1
318564142020Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B.12
322483842020CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population.1
305381182019TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress.14
307187682019Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression.15
312370252019CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.15

Citation

Dessen P

CDC25B (cell division cycle 25B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40005/js/meetings/cancer-prone-explorer/