CDK10 (cyclin dependent kinase 10)

2003-12-01  

Identity

HGNC
CDK10
LOCATION
16q24.3
LOCUSID
8558
ALIAS
ALSAS,PISSLRE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8558
MIM: 603464
HGNC: 1770
Ensembl: ENSG00000185324

Variants:

dbSNP: 8558
ClinVar: 8558
TCGA: ENSG00000185324
COSMIC: CDK10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185324ENST00000331006F8W872
ENSG00000185324ENST00000353379Q15131
ENSG00000185324ENST00000502547D6REZ2
ENSG00000185324ENST00000505473Q15131
ENSG00000185324ENST00000508723D6RA59
ENSG00000185324ENST00000510811Q9UHL7
ENSG00000185324ENST00000511415D6RHH3
ENSG00000185324ENST00000512912D6REZ2
ENSG00000185324ENST00000564192H3BT74
ENSG00000185324ENST00000565470H3BSN8
ENSG00000185324ENST00000617879Q15131
ENSG00000185324ENST00000625631Q9UHL7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377374532024CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop.1
383766062024RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma.1
377374532024CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop.1
383766062024RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma.1
365039222023A sib-pair with Al Kaissi syndrome caused by homozygosity for a novel CDK10 splice variant.1
369887712023CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.1
365039222023A sib-pair with Al Kaissi syndrome caused by homozygosity for a novel CDK10 splice variant.1
369887712023CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.1
352918762022Functional characterization of the human Cdk10/Cyclin Q complex.7
352918762022Functional characterization of the human Cdk10/Cyclin Q complex.7
343691032021Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders.1
347374402021A large Canadian cohort provides insights into the genetic architecture of human hair colour.7
343691032021Functional characterization of CDK10 and cyclin M truncated variants causing severe developmental disorders.1
347374402021A large Canadian cohort provides insights into the genetic architecture of human hair colour.7
323459882020Gene expression network analysis of lymph node involvement in colon cancer identifies AHSA2, CDK10, and CWC22 as possible prognostic markers.5

Citation

Dessen P

CDK10 (cyclin dependent kinase 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40030/deep-insight-explorer/deep-insight-explorer/case-report-explorer/