CD52 (CD52 molecule)

2003-11-01  

Identity

HGNC
CD52
LOCATION
1p36.11
LOCUSID
1043
ALIAS
CDW52,EDDM5,HE5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1043
MIM: 114280
HGNC: 1804
Ensembl: ENSG00000169442

Variants:

dbSNP: 1043
ClinVar: 1043
TCGA: ENSG00000169442
COSMIC: CD52

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169442ENST00000374213P31358
ENSG00000169442ENST00000374213V9HWN9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

References

Pubmed IDYearTitleCitations
379755352024CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma.0
379755352024CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma.0
373143542023Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia.40
373143542023Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia.40
337053532021High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes.2
337053532021High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes.2
328756082020Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia.2
336589992020CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function.12
328756082020Mutations in PIGA cause a CD52-/GPI-anchor-deficient phenotype complicating alemtuzumab treatment in T-cell prolymphocytic leukemia.2
336589992020CD52 Is Elevated on B cells of SLE Patients and Regulates B Cell Function.12
294274182018High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor(-)/CD52(-) T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation.3
299971732018CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.29
294274182018High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor(-)/CD52(-) T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation.3
299971732018CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.29
247995222014Identification of campath-1 (CD52) as novel drug target in neoplastic stem cells in 5q-patients with MDS and AML.20

Citation

Dessen P

CD52 (CD52 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40043/gene-fusions-explorer/cancer-prone-explorer/meetings/