CHD4 (chromodomain helicase DNA binding protein 4)

2003-05-01  

Identity

HGNC
CHD4
LOCATION
12p13.31
LOCUSID
1108
ALIAS
CHD-4,Mi-2b,Mi2-BETA,SIHIWES
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1108
MIM: 603277
HGNC: 1919
Ensembl: ENSG00000111642

Variants:

dbSNP: 1108
ClinVar: 1108
TCGA: ENSG00000111642
COSMIC: CHD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111642ENST00000357008A0A2U3TZM0
ENSG00000111642ENST00000544040Q14839
ENSG00000111642ENST00000544484A0A0C4DGG9
ENSG00000111642ENST00000545584F5H596
ENSG00000111642ENST00000545942F5H6N4
ENSG00000111642ENST00000642594A0A2R8Y425
ENSG00000111642ENST00000642637A0A2R8YE38
ENSG00000111642ENST00000642810A0A2R8Y5Z7
ENSG00000111642ENST00000642879A0A2R8Y521
ENSG00000111642ENST00000642893A0A2R8Y512
ENSG00000111642ENST00000643335A0A2R8YFD8
ENSG00000111642ENST00000643538A0A2R8Y5M9
ENSG00000111642ENST00000643815A0A2R8YD40
ENSG00000111642ENST00000644077A0A2R8Y7M9
ENSG00000111642ENST00000644132A0A2R8Y539
ENSG00000111642ENST00000644137A0A2R8YER1
ENSG00000111642ENST00000644289A0A2R8Y8C1
ENSG00000111642ENST00000644352A0A2R8YDW2
ENSG00000111642ENST00000644652A0A2R8Y6G9
ENSG00000111642ENST00000644801A0A2R8Y8B3
ENSG00000111642ENST00000645005A0A2R8Y212
ENSG00000111642ENST00000645022F5GWX5
ENSG00000111642ENST00000645095Q14839
ENSG00000111642ENST00000645143A0A2R8Y795
ENSG00000111642ENST00000645645A0A2R8YFK9
ENSG00000111642ENST00000645991A0A2R8Y7X1
ENSG00000111642ENST00000646268A0A2R8Y685
ENSG00000111642ENST00000646462A0A2R8Y7I0
ENSG00000111642ENST00000646608A0A2R8YDJ9
ENSG00000111642ENST00000646806A0A2R8Y5J0
ENSG00000111642ENST00000647483A0A2R8Y4X2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748224vorinostatChemicalMultilinkAnnotationassociated26296641

References

Pubmed IDYearTitleCitations
379632102024The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture.2
382680322024Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.0
382811862024Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4.0
386193232024CHD4 and SMYD1 repress common transcriptional programs in the developing heart.2
387616482024FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma.0
379632102024The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture.2
382680322024Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.0
382811862024Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4.0
386193232024CHD4 and SMYD1 repress common transcriptional programs in the developing heart.2
387616482024FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma.0
366818352023The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer.5
368129142023Epigenetic regulation of plastin 3 expression by the macrosatellite DXZ4 and the transcriptional regulator CHD4.0
369137412023The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo.2
369950662023Dermatomyositis autoantigen CHD4 forms immune stimulatory complexes with endogenous DNA.0
372547942023Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1.3

Citation

Dessen P

CHD4 (chromodomain helicase DNA binding protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40072/deep-insight-explorer/gene-fusions-explorer/hgnc