CHI3L1 (chitinase 3 like 1)

2003-02-01  

Identity

HGNC
CHI3L1
LOCATION
1q32.1
LOCUSID
1116
ALIAS
ASRT7,CGP-39,GP-39,GP39,HC-gp39,HCGP-3P,YK-40,YKL-40,YKL40,YYL-40,hCGP-39
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1116
MIM: 601525
HGNC: 1932
Ensembl: ENSG00000133048

Variants:

dbSNP: 1116
ClinVar: 1116
TCGA: ENSG00000133048
COSMIC: CHI3L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133048ENST00000255409P36222
ENSG00000133048ENST00000255409A0A024R969
ENSG00000133048ENST00000404436H0Y3U8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
376900712024Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression.9
381599692024Clinical Significance of Chitinase-3-like Protein 1 Gene Expression in Patients With Locally Advanced Gastric Cancer.0
382900902024Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia.0
382905912024TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation.2
383209882024A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1.1
385335562024YKL40 potentially via activating the P38 pathway in decreasing atherosclerotic plaque stability.0
386346212024YKL-40 Knockdown Decreases Oxidative Stress Damage in Ovarian Granulosa Cells.0
386672932024Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation.0
376900712024Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer's disease progression.9
381599692024Clinical Significance of Chitinase-3-like Protein 1 Gene Expression in Patients With Locally Advanced Gastric Cancer.0
382900902024Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia.0
382905912024TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation.2
383209882024A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1.1
385335562024YKL40 potentially via activating the P38 pathway in decreasing atherosclerotic plaque stability.0
386346212024YKL-40 Knockdown Decreases Oxidative Stress Damage in Ovarian Granulosa Cells.0

Citation

Dessen P

CHI3L1 (chitinase 3 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40075/css/js/teaching-explorer/