CLEC10A (C-type lectin domain containing 10A)

2003-06-01  

Identity

HGNC
CLEC10A
LOCATION
17p13.1
LOCUSID
10462
ALIAS
CD301,CLECSF13,CLECSF14,HML,HML2,MGL

Other Information

Locus ID:

NCBI: 10462
MIM: 605999
HGNC: 16916
Ensembl: ENSG00000132514

Variants:

dbSNP: 10462
ClinVar: 10462
TCGA: ENSG00000132514
COSMIC: CLEC10A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132514ENST00000254868Q8IUN9
ENSG00000132514ENST00000416562J3KR22
ENSG00000132514ENST00000571664Q8IUN9
ENSG00000132514ENST00000576549I3NI09
ENSG00000132514ENST00000576617Q8IUN9

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350937312022High expression of CLEC10A in head and neck squamous cell carcinoma indicates favorable prognosis and high-level immune infiltration status.1
350937312022High expression of CLEC10A in head and neck squamous cell carcinoma indicates favorable prognosis and high-level immune infiltration status.1
319112412020Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines.17
327522592020N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity.6
319112412020Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines.17
327522592020N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity.6
305826982019Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.10
312196602019The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid.12
305826982019Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells.10
312196602019The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid.12
297554532018CLEC10A Is a Specific Marker for Human CD1c(+) Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.59
297554532018CLEC10A Is a Specific Marker for Human CD1c(+) Dendritic Cells and Enhances Their Toll-Like Receptor 7/8-Induced Cytokine Secretion.59
277068072017Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis.13
277068072017Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis.13
261479702015The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.12

Citation

Dessen P

CLEC10A (C-type lectin domain containing 10A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40100/favicon/case-report-explorer/