COPS4 (COP9 signalosome subunit 4)

2003-05-01  

Identity

HGNC
COPS4
LOCATION
4q21.22
LOCUSID
51138
ALIAS
CSN4,SGN4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51138
MIM: 616008
HGNC: 16702
Ensembl: ENSG00000138663

Variants:

dbSNP: 51138
ClinVar: 51138
TCGA: ENSG00000138663
COSMIC: COPS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138663ENST00000264389Q9BT78
ENSG00000138663ENST00000264389A0A0S2Z5H7
ENSG00000138663ENST00000503682D6RFN0
ENSG00000138663ENST00000507376D6REK7
ENSG00000138663ENST00000509093Q9BT78
ENSG00000138663ENST00000509317D6RD63
ENSG00000138663ENST00000511653D6RAX7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
309922532019[Effects of CSN4 knockdown on proliferation and apoptosis of breast cancer MDA-MB-231 cells].3
309922532019[Effects of CSN4 knockdown on proliferation and apoptosis of breast cancer MDA-MB-231 cells].3
247250842014COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.5
247250842014COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.5
211024082011CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.23
211024082011CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.23
118246162002Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).23
118246162002Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21).23

Citation

Dessen P

COPS4 (COP9 signalosome subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40133/tumors-explorer/favicon/welcome