CSK (C-terminal Src kinase)

2003-02-01 Affiliation

Identity

HGNC

CSK

LOCATION

15q24.1

LOCUSID

1445

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1445
MIM: 124095
HGNC: 2444
Ensembl: ENSG00000103653

Variants:

dbSNP: 1445
ClinVar: 1445
TCGA: ENSG00000103653
COSMIC: CSK

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103653	ENST00000220003	P41240
ENSG00000103653	ENST00000220003	B2R6Q4
ENSG00000103653	ENST00000439220	P41240
ENSG00000103653	ENST00000439220	B2R6Q4
ENSG00000103653	ENST00000567123	H3BU69
ENSG00000103653	ENST00000567571	P41240
ENSG00000103653	ENST00000567571	B2R6Q4
ENSG00000103653	ENST00000569462	H3BUM9
ENSG00000103653	ENST00000569915	H3BN15

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Epithelial cell signaling in Helicobacter pylori infection	KEGG	ko05120
Epithelial cell signaling in Helicobacter pylori infection	KEGG	hsa05120
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Phosphorylation of CD3 and TCR zeta chains	REACTOME	R-HSA-202427
Costimulation by the CD28 family	REACTOME	R-HSA-388841
PD-1 signaling	REACTOME	R-HSA-389948
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
MAP2K and MAPK activation	REACTOME	R-HSA-5674135
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Integrin alphaIIb beta3 signaling	REACTOME	R-HSA-354192
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
RET signaling	REACTOME	R-HSA-8853659
Oncogenic MAPK signaling	REACTOME	R-HSA-6802957
Signaling by RAS mutants	REACTOME	R-HSA-6802949
Signaling by high-kinase activity BRAF mutants	REACTOME	R-HSA-6802948
Signaling by moderate kinase activity BRAF mutants	REACTOME	R-HSA-6802946
Paradoxical activation of RAF signaling by kinase inactive BRAF	REACTOME	R-HSA-6802955
Signaling by BRAF and RAF fusions	REACTOME	R-HSA-6802952

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA30086	KDR	Gene	Pathway	associated		20124951
PA34183	RAF1	Gene	Pathway	associated		20124951
PA444552	Hypertension	Disease	ClinicalAnnotation	associated	PD	31327267
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation	associated	PD	31327267

References

Pubmed ID	Year	Title	Citations
35393453	2022	SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.	4
35393453	2022	SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.	4
33887528	2021	Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets.	6
33887528	2021	Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets.	6
32201077	2020	CSK promotes innate immune response to DNA virus by phosphorylating MITA.	10
32376886	2020	Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.	2
32201077	2020	CSK promotes innate immune response to DNA virus by phosphorylating MITA.	10
32376886	2020	Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.	2
31125786	2019	SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.	5
31292214	2019	Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling.	3
31125786	2019	SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.	5
31292214	2019	Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling.	3
29503074	2018	Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.	21
30041015	2018	Oligodendrocyte differentiation from human neural stem cells: A novel role for c-Src.	5
30116247	2018	Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.	8

Citation

Dessen P

CSK (C-terminal Src kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40166/gene-explorer/hgnc