CSNK1E (casein kinase 1 epsilon)

2003-11-01 Affiliation

Identity

HGNC

CSNK1E

LOCATION

22q13.1

LOCUSID

1454

ALIAS

CKIe,CKIepsilon,HCKIE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1454
MIM: 600863
HGNC: 2453
Ensembl: ENSG00000213923

Variants:

dbSNP: 1454
ClinVar: 1454
TCGA: ENSG00000213923
COSMIC: CSNK1E

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000213923	ENST00000359867	P49674
ENSG00000213923	ENST00000359867	Q5U045
ENSG00000213923	ENST00000366216	H0Y5S9
ENSG00000213923	ENST00000396832	P49674
ENSG00000213923	ENST00000396832	Q5U045
ENSG00000213923	ENST00000403904	P49674
ENSG00000213923	ENST00000403904	Q5U045
ENSG00000213923	ENST00000405675	B0QY35
ENSG00000213923	ENST00000413574	B0QY34
ENSG00000213923	ENST00000430335	B0QY36
ENSG00000213923	ENST00000431611	H7C3J2
ENSG00000213923	ENST00000431632	H0Y682
ENSG00000213923	ENST00000442216	H7C0Y5
ENSG00000213923	ENST00000451964	H0Y645

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Wnt signaling pathway	KEGG	ko04310
Hedgehog signaling pathway	KEGG	ko04340
Circadian rhythm	KEGG	ko04710
Wnt signaling pathway	KEGG	hsa04310
Hedgehog signaling pathway	KEGG	hsa04340
Circadian rhythm	KEGG	hsa04710
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
FoxO signaling pathway	KEGG	hsa04068
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Anchoring of the basal body to the plasma membrane	REACTOME	R-HSA-5620912
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Wnt	REACTOME	R-HSA-195721
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
WNT mediated activation of DVL	REACTOME	R-HSA-201688
Gene Expression	REACTOME	R-HSA-74160
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Centrosome maturation	REACTOME	R-HSA-380287
Recruitment of mitotic centrosome proteins and complexes	REACTOME	R-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosome	REACTOME	R-HSA-380284
Loss of Nlp from mitotic centrosomes	REACTOME	R-HSA-380259
Circadian Clock	REACTOME	R-HSA-400253
AURKA Activation by TPX2	REACTOME	R-HSA-8854518
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
Hippo signaling pathway -multiple species	KEGG	ko04392
Hippo signaling pathway -multiple species	KEGG	hsa04392
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated		PD
PA452619	heroin	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
37787983	2023	CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.	0
37787983	2023	CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.	0
32175635	2020	Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway.	5
32321936	2020	CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.	5
32871831	2020	Cytoplasmic CK1ε Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma.	1
32888647	2020	The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.	2
32899434	2020	Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X.	0
32175635	2020	Casein kinase 1 epsilon facilitates cartilage destruction in osteoarthritis through JNK pathway.	5
32321936	2020	CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.	5
32871831	2020	Cytoplasmic CK1ε Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma.	1
32888647	2020	The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling.	2
32899434	2020	Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X.	0
30488659	2019	A de novo pathogenic CSNK1E mutation identified by exome sequencing in family trios with epileptic encephalopathy.	6
31000703	2019	Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.	10
31235588	2019	Long noncoding RNA LINC00673-v4 promotes aggressiveness of lung adenocarcinoma via activating WNT/β-catenin signaling.	56

Citation

Dessen P

CSNK1E (casein kinase 1 epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40170/gene-fusions-explorer/js/favicon/humanGenome