DMC1 (DNA meiotic recombinase 1)

2003-11-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
DMC1H,LIM15,dJ199H16.1
FUSION GENES

Other Information

Locus ID:

NCBI: 11144
MIM: 602721
HGNC: 2927
Ensembl: ENSG00000100206

Variants:

dbSNP: 11144
ClinVar: 11144
TCGA: ENSG00000100206
COSMIC: DMC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100206ENST00000216024Q14565
ENSG00000100206ENST00000415483B0QYE1
ENSG00000100206ENST00000428462Q14565
ENSG00000100206ENST00000439567B0QYE0
ENSG00000100206ENST00000616615Q8IYL1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381425952024Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.2
381425952024Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.2
378911732023FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.2
378911732023FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.2
355700722022Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?0
357296972022Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1.0
359465372022MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.1
355700722022Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?0
357296972022Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1.0
359465372022MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.1
334466542021Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.12
345157952021A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans.6
348714382021Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination.14
334466542021Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.12
345157952021A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans.6

Citation

Dessen P

DMC1 (DNA meiotic recombinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40337/gene-fusions-explorer/deep-insight-explorer/gene-fusions/?id=40337