DMC1 (DNA meiotic recombinase 1)

2003-11-01  

Identity

HGNC
DMC1
LOCATION
22q13.1
LOCUSID
11144
ALIAS
DMC1H,LIM15,dJ199H16.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11144
MIM: 602721
HGNC: 2927
Ensembl: ENSG00000100206

Variants:

dbSNP: 11144
ClinVar: 11144
TCGA: ENSG00000100206
COSMIC: DMC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100206ENST00000216024Q14565
ENSG00000100206ENST00000415483B0QYE1
ENSG00000100206ENST00000428462Q14565
ENSG00000100206ENST00000439567B0QYE0
ENSG00000100206ENST00000616615Q8IYL1

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381425952024Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.2
381425952024Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication.2
378911732023FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.2
378911732023FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.2
355700722022Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?0
357296972022Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1.0
359465372022MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.1
355700722022Can PCNA and LIM15 gene expression levels predict sperm retrieval success in men with non-obstructive azoospermia?0
357296972022Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1.0
359465372022MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.1
334466542021Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.12
345157952021A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans.6
348714382021Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination.14
334466542021Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.12
345157952021A pathogenic DMC1 frameshift mutation causes nonobstructive azoospermia but not primary ovarian insufficiency in humans.6

Citation

Dessen P

DMC1 (DNA meiotic recombinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40337/gene-fusions-explorer/deep-insight-explorer/gene-fusions/?id=40337