E2F2 (E2F transcription factor 2)

2003-02-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
E2F-2

Other Information

Locus ID:

NCBI: 1870
MIM: 600426
HGNC: 3114
Ensembl: ENSG00000007968

Variants:

dbSNP: 1870
ClinVar: 1870
TCGA: ENSG00000007968
COSMIC: E2F2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007968ENST00000361729Q14209

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Pancreatic cancerKEGGko05212
GliomaKEGGko05214
Prostate cancerKEGGko05215
MelanomaKEGGko05218
Bladder cancerKEGGko05219
Chronic myeloid leukemiaKEGGko05220
Small cell lung cancerKEGGko05222
Non-small cell lung cancerKEGGko05223
Cell cycleKEGGhsa04110
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
GliomaKEGGhsa05214
Prostate cancerKEGGhsa05215
MelanomaKEGGhsa05218
Bladder cancerKEGGhsa05219
Chronic myeloid leukemiaKEGGhsa05220
Small cell lung cancerKEGGhsa05222
Non-small cell lung cancerKEGGhsa05223
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hepatitis BKEGGhsa05161
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Regulation of DNA replicationREACTOMER-HSA-69304
Association of licensing factors with the pre-replicative complexREACTOMER-HSA-69298
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Assembly of the pre-replicative complexREACTOMER-HSA-68867
CDC6 association with the ORC:origin complexREACTOMER-HSA-68689
DNA ReplicationREACTOMER-HSA-69306
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197483572009miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.297
171352492007An E2F/miR-20a autoregulatory feedback loop.238
124114952002Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.96
204189482010MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.87
202260852010Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.80
183450302008A role for Myc in facilitating transcription activation by E2F1.45
208555242010Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.45
179169082008Survivin repression by p53, Rb and E2F2 in normal human melanocytes.38
173416212006Expression of the E2F family of transcription factors and its clinical relevance in ovarian cancer.31
229998192012miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2.27

Citation

Dessen P

E2F2 (E2F transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40383/e2f2