EI24 (EI24 autophagy associated transmembrane protein)

2003-02-01  

Identity

HGNC
EI24
LOCATION
11q24.2
LOCUSID
9538
ALIAS
EPG4,PIG8,TP53I8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9538
MIM: 605170
HGNC: 13276
Ensembl: ENSG00000149547

Variants:

dbSNP: 9538
ClinVar: 9538
TCGA: ENSG00000149547
COSMIC: EI24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149547ENST00000278903O14681
ENSG00000149547ENST00000278903A0A024R3I8
ENSG00000149547ENST00000524723E9PS58
ENSG00000149547ENST00000527131E9PL33
ENSG00000149547ENST00000527235E9PK61
ENSG00000149547ENST00000527520E9PLB8
ENSG00000149547ENST00000527842E9PM05
ENSG00000149547ENST00000529812E9PQN7
ENSG00000149547ENST00000531636A0A087WV44
ENSG00000149547ENST00000534546O14681
ENSG00000149547ENST00000615917B7ZB74
ENSG00000149547ENST00000618552B7ZB74
ENSG00000149547ENST00000620753O14681
ENSG00000149547ENST00000620753A0A024R3I8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
341094322021miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24.3
341094322021miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24.3
307849132019Integrated analysis of the prognostic value of TP53 dependent etoposide-induced gene 24 in non-small cell lung cancer.0
307849132019Integrated analysis of the prognostic value of TP53 dependent etoposide-induced gene 24 in non-small cell lung cancer.0
280384502017MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24.40
280384502017MicroRNA-455-3p promotes invasion and migration in triple negative breast cancer by targeting tumor suppressor EI24.40
275417282016Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases.17
275417282016Functional characterization of EI24-induced autophagy in the degradation of RING-domain E3 ligases.17
263425512015Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells.3
263425512015Reduced expression of EI24 confers resistance to gefitinib through IGF-1R signaling in PC9 NSCLC cells.3
248218382014The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.16
248218382014The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain.16
240140292013Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.8
242803712013EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.18
240140292013Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation.8

Citation

Dessen P

EI24 (EI24 autophagy associated transmembrane protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40422/teaching-explorer/haematological-explorer/