EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

2003-02-01 Affiliation

Identity

HGNC

EIF4G1

LOCATION

3q27.1

LOCUSID

1981

ALIAS

EIF-4G1,EIF4F,EIF4G,EIF4GI,P220,PARK18

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1981
MIM: 600495
HGNC: 3296
Ensembl: ENSG00000114867

Variants:

dbSNP: 1981
ClinVar: 1981
TCGA: ENSG00000114867
COSMIC: EIF4G1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114867	ENST00000342981	Q04637
ENSG00000114867	ENST00000346169	Q04637
ENSG00000114867	ENST00000350481	Q04637
ENSG00000114867	ENST00000352767	Q04637
ENSG00000114867	ENST00000382330	Q04637
ENSG00000114867	ENST00000392537	Q04637
ENSG00000114867	ENST00000411531	E7EUU4
ENSG00000114867	ENST00000413967	F8WB97
ENSG00000114867	ENST00000414031	Q04637
ENSG00000114867	ENST00000421110	C9K073
ENSG00000114867	ENST00000422614	H7C0V6
ENSG00000114867	ENST00000424196	Q04637
ENSG00000114867	ENST00000426123	C9JF13
ENSG00000114867	ENST00000427141	C9J987
ENSG00000114867	ENST00000427607	C9JSU8
ENSG00000114867	ENST00000427845	E9PGM1
ENSG00000114867	ENST00000428387	C9J556
ENSG00000114867	ENST00000434061	Q04637
ENSG00000114867	ENST00000435046	Q04637
ENSG00000114867	ENST00000440448	C9JWH9
ENSG00000114867	ENST00000441154	E7EX73
ENSG00000114867	ENST00000442406	F8WCF2
ENSG00000114867	ENST00000444134	C9JWH7
ENSG00000114867	ENST00000444861	C9J6B6
ENSG00000114867	ENST00000448284	H7C044
ENSG00000114867	ENST00000450424	C9J2Z7
ENSG00000114867	ENST00000455679	C9JIH5
ENSG00000114867	ENST00000456033	C9JHW9
ENSG00000114867	ENST00000457456	C9JWW9

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Viral myocarditis	KEGG	hsa05416
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
eIF4F complex	KEGG	hsa_M00428
eIF4F complex	KEGG	M00428
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	REACTOME	R-HSA-72662
Translation initiation complex formation	REACTOME	R-HSA-72649
Ribosomal scanning and start codon recognition	REACTOME	R-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Antiviral mechanism by IFN-stimulated genes	REACTOME	R-HSA-1169410
ISG15 antiviral mechanism	REACTOME	R-HSA-1169408
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
mTORC1-mediated signalling	REACTOME	R-HSA-166208
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Deadenylation-dependent mRNA decay	REACTOME	R-HSA-429914
Deadenylation of mRNA	REACTOME	R-HSA-429947
Nonsense-Mediated Decay (NMD)	REACTOME	R-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	REACTOME	R-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	REACTOME	R-HSA-975956
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
AUF1 (hnRNP D0) binds and destabilizes mRNA	REACTOME	R-HSA-450408

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38266053	2024	Computational inference of eIF4F complex function and structure in human cancers.	0
38266053	2024	Computational inference of eIF4F complex function and structure in human cancers.	0
36897548	2023	Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.	1
37132650	2023	Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs.	1
37724583	2023	The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.	1
36897548	2023	Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.	1
37132650	2023	Thermodynamically Favorable Interactions between eIF4E Binding Domain of eIF4GI with Structured 5'-Untranslated Regions Drive Cap-Independent Translation of Selected mRNAs.	1
37724583	2023	The Insulin Receptor and Insulin like Growth Factor Receptor 5' UTRs Support Translation Initiation Independently of EIF4G1.	1
35163752	2022	Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.	0
35857873	2022	Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.	6
36551184	2022	EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.	2
35163752	2022	Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia.	0
35857873	2022	Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation.	6
36551184	2022	EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.	2
33239198	2021	Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.	11

Citation

Dessen P

EIF4G1 (eukaryotic translation initiation factor 4 gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40433/img/js/lib/meetings/