EPHA5 (EPH receptor A5)

2003-02-01  

Identity

HGNC
EPHA5
LOCATION
4q13.1
LOCUSID
2044
ALIAS
CEK7,EHK-1,EHK1,EK7,HEK7,TYRO4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2044
MIM: 600004
HGNC: 3389
Ensembl: ENSG00000145242

Variants:

dbSNP: 2044
ClinVar: 2044
TCGA: ENSG00000145242
COSMIC: EPHA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145242ENST00000273854P54756
ENSG00000145242ENST00000273854A0A384MU00
ENSG00000145242ENST00000354839P54756
ENSG00000145242ENST00000432638F8W9W0
ENSG00000145242ENST00000511294F8VP57
ENSG00000145242ENST00000613740B7ZKW7
ENSG00000145242ENST00000622150B7ZKJ3

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD22843789, 26133776, 26133777, 26763541
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPD22843789, 26133776, 26133777, 26763541
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD22843789, 26133776, 26133777, 26763541

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
167375512006Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival.30
197338952010Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer.25
199499122010Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma.17
256091952015Downregulation of EphA5 by promoter methylation in human prostate cancer.12
240291322013After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate.10
256230652015Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer.10
220796382011MicroRNA-34a regulates migration of chondroblast and IL-1β-induced degeneration of chondrocytes by targeting EphA5.8
240863082013Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations.8
275824842017Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.5

Citation

Dessen P

EPHA5 (EPH receptor A5)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40465/epha5-(eph-receptor-a5)