ERBB4 (erb-b2 receptor tyrosine kinase 4)

2003-02-01 Affiliation

Identity

HGNC

ERBB4

LOCATION

2q34

LOCUSID

2066

ALIAS

ALS19,HER4,p180erbB4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2066
MIM: 600543
HGNC: 3432
Ensembl: ENSG00000178568

Variants:

dbSNP: 2066
ClinVar: 2066
TCGA: ENSG00000178568
COSMIC: ERBB4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178568	ENST00000260943	H3BLT0
ENSG00000178568	ENST00000342788	Q15303
ENSG00000178568	ENST00000402597	A0A0A0MSE1
ENSG00000178568	ENST00000435846	E9PDR1
ENSG00000178568	ENST00000436443	Q15303

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
Calcium signaling pathway	KEGG	ko04020
ErbB signaling pathway	KEGG	hsa04012
Calcium signaling pathway	KEGG	hsa04020
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
GRB2 events in ERBB2 signaling	REACTOME	R-HSA-1963640
PI3K events in ERBB2 signaling	REACTOME	R-HSA-1963642
Signaling by ERBB4	REACTOME	R-HSA-1236394
SHC1 events in ERBB4 signaling	REACTOME	R-HSA-1250347
PI3K events in ERBB4 signaling	REACTOME	R-HSA-1250342
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985
Downregulation of ERBB4 signaling	REACTOME	R-HSA-1253288
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
ERBB2 Regulates Cell Motility	REACTOME	R-HSA-6785631
ERBB2 Activates PTK6 Signaling	REACTOME	R-HSA-8847993
Signaling by PTK6	REACTOME	R-HSA-8848021
RET signaling	REACTOME	R-HSA-8853659
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA131301952	gefitinib	Chemical	Pathway	associated
PA134687924	erlotinib	Chemical	Pathway	associated
PA152241907	lapatinib	Chemical	Pathway	associated
PA163518919	paliperidone	Chemical	MultilinkAnnotation	associated	25714000
PA29988	JAK1	Gene	Pathway	associated
PA33308	PIK3CA	Gene	Pathway	associated
PA33309	PIK3CB	Gene	Pathway	associated
PA33310	PIK3CD	Gene	Pathway	associated
PA33311	PIK3CG	Gene	Pathway	associated
PA33312	PIK3R1	Gene	Pathway	associated
PA33313	PIK3R2	Gene	Pathway	associated
PA33314	PIK3R3	Gene	Pathway	associated
PA33392	PLCG1	Gene	Pathway	associated
PA33393	PLCG2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
37870708	2024	Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan.	0
38369520	2024	Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.	2
37870708	2024	Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan.	0
38369520	2024	Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer.	2
36584483	2023	Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.	1
37196148	2023	miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4.	2
37290686	2023	MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4.	1
37369570	2023	NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders.	3
38063127	2023	ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.	1
38149095	2023	Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study.	1
36584483	2023	Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.	1
37196148	2023	miR-433 Inhibits Glioblastoma Progression by Suppressing the PI3K/Akt Signaling Pathway Through Direct Targeting of ERBB4.	2
37290686	2023	MicroRNA-23a-3p Is Upregulated in Plasma Exosomes of Bulbar-onset ALS Patients and Targets ERBB4.	1
37369570	2023	NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders.	3
38063127	2023	ErbB4 affects Th1/Th17 cell differentiation and promotes psoriasis progression.	1

Citation

Dessen P

ERBB4 (erb-b2 receptor tyrosine kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40480/tumors-explorer/case-report-explorer/