FADD (Fas associated via death domain)

2003-06-01  

Identity

HGNC
FADD
LOCATION
11q13.3
LOCUSID
8772
ALIAS
GIG3,MORT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8772
MIM: 602457
HGNC: 3573
Ensembl: ENSG00000168040

Variants:

dbSNP: 8772
ClinVar: 8772
TCGA: ENSG00000168040
COSMIC: FADD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168040ENST00000301838Q13158

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Toll-like receptor signaling pathwayKEGGko04620
Alzheimer's diseaseKEGGko05010
ApoptosisKEGGhsa04210
Toll-like receptor signaling pathwayKEGGhsa04620
Alzheimer's diseaseKEGGhsa05010
Pathways in cancerKEGGhsa05200
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Hepatitis BKEGGhsa05161
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
FasL/ CD95L signalingREACTOMER-HSA-75157
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
TRAIL signalingREACTOMER-HSA-75158
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Dimerization of procaspase-8REACTOMER-HSA-69416
Regulation by c-FLIPREACTOMER-HSA-3371378
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460
Regulation of necroptotic cell deathREACTOMER-HSA-5675482
CASP8 activity is inhibitedREACTOMER-HSA-5218900
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377935712024Combined germline and somatic human FADD mutations cause autoimmune lymphoproliferative syndrome.2
379797022024Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.1
387107042024Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.0
377935712024Combined germline and somatic human FADD mutations cause autoimmune lymphoproliferative syndrome.2
379797022024Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing.1
387107042024Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.0
362815352023FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition.3
368139502023Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma.1
371469682023The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity.0
362815352023FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition.3
368139502023Prognostic significance and immune correlates of FADD in penile squamous cell carcinoma.1
371469682023The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity.0
356379512022The Classical Apoptotic Adaptor FADD Regulates Glycolytic Capacity in Acute Lymphoblastic Leukemia.2
364994822022A Dual Role for FADD in Human Precursor T-Cell Neoplasms.0
356379512022The Classical Apoptotic Adaptor FADD Regulates Glycolytic Capacity in Acute Lymphoblastic Leukemia.2

Citation

Dessen P

FADD (Fas associated via death domain)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40525/js/lib/meetings/deep-insight-explorer/