FGF16 (fibroblast growth factor 16)

2003-06-01 Affiliation

Identity

HGNC

FGF16

LOCATION

Xq21.1

LOCUSID

8823

ALIAS

FGF-16,MF4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8823
MIM: 309630
HGNC: 3672
Ensembl: ENSG00000196468

Variants:

dbSNP: 8823
ClinVar: 8823
TCGA: ENSG00000196468
COSMIC: FGF16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000196468	ENST00000439435	O43320

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Regulation of actin cytoskeleton	KEGG	ko04810
Melanoma	KEGG	ko05218
MAPK signaling pathway	KEGG	hsa04010
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Melanoma	KEGG	hsa05218
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR2 in disease	REACTOME	R-HSA-5655253
FGFR2 mutant receptor activation	REACTOME	R-HSA-1839126
Activated point mutants of FGFR2	REACTOME	R-HSA-2033519
Signaling by FGFR3 in disease	REACTOME	R-HSA-5655332
FGFR3 mutant receptor activation	REACTOME	R-HSA-2033514
Signaling by activated point mutants of FGFR3	REACTOME	R-HSA-1839130
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR2	REACTOME	R-HSA-5654738
FGFR2 ligand binding and activation	REACTOME	R-HSA-190241
FGFR2c ligand binding and activation	REACTOME	R-HSA-190375
Downstream signaling of activated FGFR2	REACTOME	R-HSA-5654696
FRS-mediated FGFR2 signaling	REACTOME	R-HSA-5654700
Phospholipase C-mediated cascade; FGFR2	REACTOME	R-HSA-5654221
SHC-mediated cascade:FGFR2	REACTOME	R-HSA-5654699
PI-3K cascade:FGFR2	REACTOME	R-HSA-5654695
Negative regulation of FGFR2 signaling	REACTOME	R-HSA-5654727
Signaling by FGFR3	REACTOME	R-HSA-5654741
FGFR3 ligand binding and activation	REACTOME	R-HSA-190239
FGFR3c ligand binding and activation	REACTOME	R-HSA-190372
Downstream signaling of activated FGFR3	REACTOME	R-HSA-5654708
FRS-mediated FGFR3 signaling	REACTOME	R-HSA-5654706
Phospholipase C-mediated cascade; FGFR3	REACTOME	R-HSA-5654227
SHC-mediated cascade:FGFR3	REACTOME	R-HSA-5654704
PI-3K cascade:FGFR3	REACTOME	R-HSA-5654710
Negative regulation of FGFR3 signaling	REACTOME	R-HSA-5654732
Signaling by FGFR4	REACTOME	R-HSA-5654743
FGFR4 ligand binding and activation	REACTOME	R-HSA-190322
Downstream signaling of activated FGFR4	REACTOME	R-HSA-5654716
FRS-mediated FGFR4 signaling	REACTOME	R-HSA-5654712
Phospholipase C-mediated cascade; FGFR4	REACTOME	R-HSA-5654228
SHC-mediated cascade:FGFR4	REACTOME	R-HSA-5654719
PI-3K cascade:FGFR4	REACTOME	R-HSA-5654720
Negative regulation of FGFR4 signaling	REACTOME	R-HSA-5654733
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
Signaling by FGFR3 point mutants in cancer	REACTOME	R-HSA-8853338
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

References

Pubmed ID	Year	Title	Citations
33956078	2022	Patient-specific iPSC-derived cardiomyocytes reveal abnormal regulation of FGF16 in a familial atrial septal defect.	8
33956078	2022	Patient-specific iPSC-derived cardiomyocytes reveal abnormal regulation of FGF16 in a familial atrial septal defect.	8
31292167	2019	MiRNA-144-3p inhibits high glucose induced cell proliferation through suppressing FGF16.	10
31801200	2019	Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells.	8
31292167	2019	MiRNA-144-3p inhibits high glucose induced cell proliferation through suppressing FGF16.	10
31801200	2019	Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells.	8
28409700	2017	High-yield of biologically active recombinant human fibroblast growth factor-16 in E. coli and its mechanism of proliferation in NCL-H460 cells.	1
28409700	2017	High-yield of biologically active recombinant human fibroblast growth factor-16 in E. coli and its mechanism of proliferation in NCL-H460 cells.	1
24706454	2014	Further evidence for FGF16 truncating mutations as the cause of X-linked recessive fusion of metacarpals 4 / 5.	2
24878828	2014	Identification of a novel familial FGF16 mutation in metacarpal 4-5 fusion.	3
24706454	2014	Further evidence for FGF16 truncating mutations as the cause of X-linked recessive fusion of metacarpals 4 / 5.	2
24878828	2014	Identification of a novel familial FGF16 mutation in metacarpal 4-5 fusion.	3
20097674	2010	FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart.	6
20097674	2010	FGF-16 is a target for adrenergic stimulation through NF-kappaB activation in postnatal cardiac cells and adult mouse heart.	6
16756958	2006	Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation.	21

Citation

Dessen P

FGF16 (fibroblast growth factor 16)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40555/tumors-explorer/teaching-explorer/humanGenome