FLT4 (fms related receptor tyrosine kinase 4)

2003-02-01  

Identity

HGNC
FLT4
LOCATION
5q35.3
LOCUSID
2324
ALIAS
CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,PCL,VEGFR-3,VEGFR3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2324
MIM: 136352
HGNC: 3767
Ensembl: ENSG00000037280

Variants:

dbSNP: 2324
ClinVar: 2324
TCGA: ENSG00000037280
COSMIC: FLT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000037280ENST00000261937P35916
ENSG00000037280ENST00000393347P35916
ENSG00000037280ENST00000502649E9PD35
ENSG00000037280ENST00000512795D6RFF2
ENSG00000037280ENST00000619105B5A927

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162372840sunitinibChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD19248971, 22015057
PA29444HRASGenePathwayassociated28362716
PA30196KRASGenePathwayassociated28362716
PA31768NRASGenePathwayassociated28362716
PA33304PIK3C2AGenePathwayassociated28362716
PA33305PIK3C2BGenePathwayassociated28362716
PA33308PIK3CAGenePathwayassociated28362716
PA33309PIK3CBGenePathwayassociated28362716
PA33310PIK3CDGenePathwayassociated28362716
PA33311PIK3CGGenePathwayassociated28362716
PA33312PIK3R1GenePathwayassociated28362716
PA33313PIK3R2GenePathwayassociated28362716
PA33314PIK3R3GenePathwayassociated28362716
PA443624Carcinoma, Renal CellDiseaseClinicalAnnotationassociatedPD22015057
PA7000sorafenibChemicalPathwayassociated28362716

References

Pubmed IDYearTitleCitations
382695892024Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.1
385181982024The pathological roles and potential mechanisms of vascular endothelial growth factor receptor-3 in gastric cancer.0
385810272024Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China.1
387289432024miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.0
382695892024Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.1
385181982024The pathological roles and potential mechanisms of vascular endothelial growth factor receptor-3 in gastric cancer.0
385810272024Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China.1
387289432024miR-455-3p regulates lymphangiogenesis in silicosis by regulating VEGF-C/VEGFR3.0
365388742023Two novel variations p.(Ser1275Thr) and p.(Ser1275Arg) in FLT4 causing prenatal hereditary lymphedema type 1.0
368350142023High VEGFR3 Expression Reduces Doxorubicin Efficacy in Triple-Negative Breast Cancer.1
369227132023VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways.1
373178802023FLT4 as a marker for predicting prognostic risk of refractory acute myeloid leukemia.0
374542902023VEGFR3 is required for button junction formation in lymphatic vessels.5
365388742023Two novel variations p.(Ser1275Thr) and p.(Ser1275Arg) in FLT4 causing prenatal hereditary lymphedema type 1.0
368350142023High VEGFR3 Expression Reduces Doxorubicin Efficacy in Triple-Negative Breast Cancer.1

Citation

Dessen P

FLT4 (fms related receptor tyrosine kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40612/css/lib/cancer-prone-explorer/deep-insight-explorer/