FNTA (farnesyltransferase, CAAX box, alpha)

2004-02-01  

Identity

HGNC
FNTA
LOCATION
8p11.21
LOCUSID
2339
ALIAS
FPTA,PGGT1A,PTAR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2339
MIM: 134635
HGNC: 3782
Ensembl: ENSG00000168522

Variants:

dbSNP: 2339
ClinVar: 2339
TCGA: ENSG00000168522
COSMIC: FNTA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168522ENST00000302279P49354
ENSG00000168522ENST00000525699E9PPM9
ENSG00000168522ENST00000526755E9PK84
ENSG00000168522ENST00000529687B3KVN2
ENSG00000168522ENST00000531266H0YCW1
ENSG00000168522ENST00000533336E9PQP6
ENSG00000168522ENST00000533383E9PK84
ENSG00000168522ENST00000533998E9PN85

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Terpenoid backbone biosynthesisKEGGko00900
Terpenoid backbone biosynthesisKEGGhsa00900
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
331124922021Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.7
343155312021Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.12
331124922021Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.7
343155312021Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.12
332575712020Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.5
332575712020Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.5
289486212017Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.3
291988242017Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.13
289486212017Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.3
291988242017Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.13
221603082012Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.29
221603082012Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.29
198418752010Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.2
204039972010Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.35
198418752010Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study.2

Citation

Dessen P

FNTA (farnesyltransferase, CAAX box, alpha)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/40618/fnta