GADD45G (growth arrest and DNA damage inducible gamma)

2003-08-01  

Identity

HGNC
GADD45G
LOCATION
9q22.2
LOCUSID
10912
ALIAS
CR6,DDIT2,GADD45gamma,GRP17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10912
MIM: 604949
HGNC: 4097
Ensembl: ENSG00000130222

Variants:

dbSNP: 10912
ClinVar: 10912
TCGA: ENSG00000130222
COSMIC: GADD45G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130222ENST00000252506O95257
ENSG00000130222ENST00000375769Q5VZ88

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
MAPK signaling pathwayKEGGhsa04010
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
FoxO signaling pathwayKEGGhsa04068

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385829022024Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.1
385829022024Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.1
378336942023Identify GADD45G as a potential target of 4-methoxydalbergione in treatment of liver cancer: bioinformatics analysis and in vivo experiment.0
378336942023Identify GADD45G as a potential target of 4-methoxydalbergione in treatment of liver cancer: bioinformatics analysis and in vivo experiment.0
342827422022Effect of GADD45G on the radioresistance of nasopharyngeal carcinoma cells.1
351376642022Circular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma.10
342827422022Effect of GADD45G on the radioresistance of nasopharyngeal carcinoma cells.1
351376642022Circular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma.10
347883112021MAGEH1 interacts with GADD45G and induces renal tubular cell apoptosis.2
347883112021MAGEH1 interacts with GADD45G and induces renal tubular cell apoptosis.2
315626122020GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.7
321386712020Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study.6
315626122020GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.7
321386712020Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study.6
307006042019GADD45γ Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes.3

Citation

Dessen P

GADD45G (growth arrest and DNA damage inducible gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40667/gene-fusions/deep-insight-explorer/