GLIPR1 (GLI pathogenesis related 1)

2003-02-01  

Identity

HGNC
GLIPR1
LOCATION
12q21.2
LOCUSID
11010
ALIAS
CRISP7,GLIPR,RTVP1

Other Information

Locus ID:

NCBI: 11010
MIM: 602692
HGNC: 17001
Ensembl: ENSG00000139278

Variants:

dbSNP: 11010
ClinVar: 11010
TCGA: ENSG00000139278
COSMIC: GLIPR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139278ENST00000266659P48060
ENSG00000139278ENST00000456650F6VVE8
ENSG00000139278ENST00000536703B4E3S5
ENSG00000139278ENST00000550491J3QTC9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383683742024Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer.0
383683742024Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer.0
337421302022Glioma pathogenesis-related protein 1 performs dual functions in tumor cells.3
357608982022GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway.0
337421302022Glioma pathogenesis-related protein 1 performs dual functions in tumor cells.3
357608982022GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway.0
336758642021GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis.4
336758642021GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis.4
319956272020GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.1
319956272020GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.1
287996732018TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.21
287996732018TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.21
287715802017GLIPR1 modulates the response of cisplatin-resistant human lung cancer cells to cisplatin.6
287715802017GLIPR1 modulates the response of cisplatin-resistant human lung cancer cells to cisplatin.6
269880962016GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.14

Citation

Dessen P

GLIPR1 (GLI pathogenesis related 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40721/css/humanGenome