GSTZ1 (glutathione S-transferase zeta 1)

2003-06-01 Affiliation

Identity

HGNC

GSTZ1

LOCATION

14q24.3

LOCUSID

2954

ALIAS

GSTZ1-1,MAAI,MAAID,MAI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2954
MIM: 603758
HGNC: 4643
Ensembl: ENSG00000100577

Variants:

dbSNP: 2954
ClinVar: 2954
TCGA: ENSG00000100577
COSMIC: GSTZ1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100577	ENST00000216465	A0A0C4DFM0
ENSG00000100577	ENST00000349555	A0A0A0MR33
ENSG00000100577	ENST00000361389	O43708
ENSG00000100577	ENST00000393734	O43708
ENSG00000100577	ENST00000553586	G3V4T6
ENSG00000100577	ENST00000554279	G3V5T0
ENSG00000100577	ENST00000554381	H0YJN8
ENSG00000100577	ENST00000554846	G3V5U6
ENSG00000100577	ENST00000555583	G3V5G8
ENSG00000100577	ENST00000556627	G3V267
ENSG00000100577	ENST00000557053	G3V3B9
ENSG00000100577	ENST00000557639	O43708

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Tyrosine metabolism	KEGG	ko00350
Tyrosine metabolism	KEGG	hsa00350
Metabolic pathways	KEGG	hsa01100
Tyrosine degradation, tyrosine => homogentisate	KEGG	M00044
Tyrosine degradation, tyrosine => homogentisate	KEGG	hsa_M00044
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Phenylalanine and tyrosine catabolism	REACTOME	R-HSA-71182
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	REACTOME	R-HSA-6788656

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA165947835	dichloroacetic acid	Chemical	MultilinkAnnotation	associated			27143230

References

Pubmed ID	Year	Title	Citations
36905252	2023	Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells.	1
37742772	2023	Clinical physiology and pharmacology of GSTZ1/MAAI.	1
36905252	2023	Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells.	1
37742772	2023	Clinical physiology and pharmacology of GSTZ1/MAAI.	1
33931597	2021	GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.	109
33931597	2021	GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.	109
31782257	2020	GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells.	5
32357971	2020	Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.	3
31782257	2020	GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells.	5
32357971	2020	Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.	3
31267557	2019	GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.	24
31624634	2019	GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.	10
31666108	2019	GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.	28
31267557	2019	GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.	24
31624634	2019	GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.	10

Citation

Dessen P

GSTZ1 (glutathione S-transferase zeta 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40776/cancer-prone-explorer/gene-explorer/