HCK (HCK proto-oncogene, Src family tyrosine kinase)

2003-02-01  

Identity

HGNC
HCK
LOCATION
20q11.21
LOCUSID
3055
ALIAS
JTK9,p59Hck,p61Hck
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3055
MIM: 142370
HGNC: 4840
Ensembl: ENSG00000101336

Variants:

dbSNP: 3055
ClinVar: 3055
TCGA: ENSG00000101336
COSMIC: HCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101336ENST00000262651H7BXG4
ENSG00000101336ENST00000375852J3KPD6
ENSG00000101336ENST00000375862H0Y3C5
ENSG00000101336ENST00000486475H7C5P9
ENSG00000101336ENST00000518730P08631
ENSG00000101336ENST00000520553P08631
ENSG00000101336ENST00000538448P08631
ENSG00000101336ENST00000629881P08631

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef and signal transductionREACTOMER-HSA-164944
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
Regulation of signaling by CBLREACTOMER-HSA-912631

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373420662023HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling.1
373420662023HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling.1
352554962022A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas.2
352804402022HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia.6
356398552022Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.14
352554962022A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas.2
352804402022HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia.6
356398552022Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.14
325916422021Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma.10
336178792021Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.3
338942732021miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK.6
341675582021HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML.4
325916422021Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma.10
336178792021Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.3
338942732021miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK.6

Citation

Dessen P

HCK (HCK proto-oncogene, Src family tyrosine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40798/deep-insight-explorer/haematological-explorer/case-report-explorer/