HPN (hepsin)

2003-02-01  

Identity

HGNC
HPN
LOCATION
19q13.11
LOCUSID
3249
ALIAS
TMPRSS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3249
MIM: 142440
HGNC: 5155
Ensembl: ENSG00000105707

Variants:

dbSNP: 3249
ClinVar: 3249
TCGA: ENSG00000105707
COSMIC: HPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105707ENST00000262626P05981
ENSG00000105707ENST00000262626A0A140VJK9
ENSG00000105707ENST00000392226P05981
ENSG00000105707ENST00000392226A0A140VJK9
ENSG00000105707ENST00000597419M0QZ63
ENSG00000105707ENST00000600390M0R244
ENSG00000105707ENST00000672452A0A140VJK9
ENSG00000105707ENST00000673426A0A140VJK9

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signal TransductionREACTOMER-HSA-162582
Signaling by MST1REACTOMER-HSA-8852405
Signaling by METREACTOMER-HSA-6806834
MET Receptor ActivationREACTOMER-HSA-6806942

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378728682024Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis.1
378728682024Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis.1
368021682023Spatial position is a key determinant of N-glycan functionality of the scavenger receptor cysteine-rich domain of human hepsin.0
370136852023N-glycosylation mediated folding and quality control in serine proteases of the hepsin family.1
368021682023Spatial position is a key determinant of N-glycan functionality of the scavenger receptor cysteine-rich domain of human hepsin.0
370136852023N-glycosylation mediated folding and quality control in serine proteases of the hepsin family.1
351647912022The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics.3
354848842022Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation.0
351647912022The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics.3
354848842022Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation.0
333002642021Hepsin: a multifunctional transmembrane serine protease in pathobiology.13
334619732021Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.6
341310222021The transmembrane serine protease hepsin suppresses type I interferon induction by cleaving STING.8
333002642021Hepsin: a multifunctional transmembrane serine protease in pathobiology.13
334619732021Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.6

Citation

Dessen P

HPN (hepsin)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40857/haematological-explorer/humanGenome