HPSE (heparanase)

2003-02-01  

Identity

HGNC
HPSE
LOCATION
4q21.23
LOCUSID
10855
ALIAS
HPA,HPA1,HPR1,HPSE1,HSE1

Other Information

Locus ID:

NCBI: 10855
MIM: 604724
HGNC: 5164
Ensembl: ENSG00000173083

Variants:

dbSNP: 10855
ClinVar: 10855
TCGA: ENSG00000173083
COSMIC: HPSE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173083ENST00000311412Q9Y251
ENSG00000173083ENST00000405413Q9Y251
ENSG00000173083ENST00000507150D6RHG4
ENSG00000173083ENST00000508891D6RAQ1
ENSG00000173083ENST00000509906Q9Y251
ENSG00000173083ENST00000512196Q9Y251
ENSG00000173083ENST00000513463Q9Y251

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
Metabolic pathwaysKEGGhsa01100
Heparan sulfate degradationKEGGhsa_M00078
Heparan sulfate degradationKEGGM00078
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG degradationREACTOMER-HSA-2024096
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
383786822024Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.0
387719532024Heparanase Stimulation of Physiologic Cardiac Hypertrophy Is Suppressed After Chronic Diabetes, Resulting in Cardiac Remodeling and Dysfunction.1
383786822024Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.0
387719532024Heparanase Stimulation of Physiologic Cardiac Hypertrophy Is Suppressed After Chronic Diabetes, Resulting in Cardiac Remodeling and Dysfunction.1
369802542023Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.0
374819972023Heparanase promotes malignant phenotypes of human oral squamous carcinoma cells by regulating the epithelial-mesenchymal transition-related molecules and infiltrated levels of natural killer cells.0
369802542023Effect of HPSE and HPSE2 SNPs on the Risk of Developing Primary Paraskeletal Multiple Myeloma.0
374819972023Heparanase promotes malignant phenotypes of human oral squamous carcinoma cells by regulating the epithelial-mesenchymal transition-related molecules and infiltrated levels of natural killer cells.0
357694882022Single-Cell Sequencing Analysis and Multiple Machine Learning Methods Identified G0S2 and HPSE as Novel Biomarkers for Abdominal Aortic Aneurysm.11
365640842022Ethnic differences in urinary monocyte chemoattractant protein-1 and heparanase-1 levels in individuals with type 2 diabetes: the HELIUS study.1
357694882022Single-Cell Sequencing Analysis and Multiple Machine Learning Methods Identified G0S2 and HPSE as Novel Biomarkers for Abdominal Aortic Aneurysm.11
365640842022Ethnic differences in urinary monocyte chemoattractant protein-1 and heparanase-1 levels in individuals with type 2 diabetes: the HELIUS study.1
324450512021Upregulation of Fecal Epithelial Heparanase mRNA Is Associated with Increased Ulcerative Colitis Activity and Cancerization Risk.0
340366832021Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma.21
341327902021Heparanase as a potential player in SARS-CoV-2 infection and induced coagulopathy.11

Citation

Dessen P

HPSE (heparanase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40858/haematological-explorer/