HSPH1 (heat shock 105kDa/110kDa protein 1)

2007-02-01 Takumi Hatayama , Nobuyuki Yamagishi Affiliation

Department of Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607-8414, Japan

Identity

HGNC

HSPH1

LOCATION

13q12.3

LOCUSID

10808

ALIAS

HSP105,HSP105A,HSP105B,NY-CO-25

FUSION GENES

Show Gene Fusions

DNA/RNA

Genomic organization of the mouse HSP105 gene. The linear map of the exon-intron structure is shown schematically. Exons are represented as numbered boxes. Two alternative splicing patterns gave rise to HSP105alpha and HSP105beta transcripts. ATG and TAG indicate the positions of initiation and termination codons, respectively. (DDBJ/EMBL/GenBank DNA databases with accession Nos. AB005267-AB005282).

Description

18 exons on 22 kb

Transcription

Hsp105alpha is transcribed constitutively and also by a variety of stresses. 4 kb mRNA Hsp105beta is an alternative spliced isoform only produced during heat shock at 42 degree.

Proteins

Shematic structures of HSP105alpha and HSP105beta proteins. Shaded box represents the spliced out region of HSP105alpha which is lacking in HSP105beta.

Description

Hsp105alpha: 858 amino acids, 105 kDa; contains an ATP binding domain (residues 1-383), b-sheet domain (residues 384-511), loop domain (residues 512-607) and alpha-helix domain (residues 608-858). Hsp105beta: 814 amino acids, 90 kDa; contains an ATP binding domain (residues 1-383), b-sheet domain (residues 384-511), loop domain (residues 512-563) and alpha-helix domain (residues 564-814).

Expression

wide, highly expressed in brain

Localisation

Hsp105alpha, cytoplasmic; Hsp105beta, nuclear

Function

Hsp105alpha and Hsp105beta suppress the aggregation of denatured proteins; function as a substitute for Hsp70 family proteins to suppress the aggregation of denatured proteins in cells under severe stress; regulate substrate binding cycle of Hsp70/Hsc70 by inhibiting the ATPase activity of Hsp70/Hsc70.

Homology

With mouse apg-1, mouse apg-2, sea urchin egg receptor, C. elegans 86.9-kDa protein, A. thaliana hsp91 and S. cerevisiae SSE1, human hsp70 and human hsc70.

Implicated in

Entity name

Lung cancers

Prognosis

Poor

Oncogenesis

Low expression of hsp105 was identified as predictors of survival in lung adenocarcinomas.

Entity name

Colorectal cancers

Prognosis

Survival is not much more than 50% after 5 years.

Oncogenesis

Overexpression of hsp105 is a late event in the colorectal adenoma-carcinoma sequence.

Bibliography

Pubmed ID	Last Year	Title	Authors
16827803	2006	Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.	Hosaka S et al
9931472	1999	Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105.	Ishihara K et al
14534695	2003	Heat shock protein 105 is overexpressed in a variety of human tumors.	Kai M et al
16232202	2005	DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells.	Miyazaki M et al
16911285	2006	Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.	Muchemwa FC et al
11237751	2001	Gene cloning of immunogenic antigens overexpressed in pancreatic cancer.	Nakatsura T et al
16857185	2006	Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells.	Yamagishi N et al
10066425	1999	Genomic cloning and promoter analysis of the mouse 105-kDa heat shock protein (HSP105) gene.	Yasuda K et al
8530361	1995	Cloning and expression of murine high molecular mass heat shock proteins, HSP105.	Yasuda K et al

Other Information

Locus ID:

NCBI: 10808
MIM: 610703
HGNC: 16969
Ensembl: ENSG00000120694

Variants:

dbSNP: 10808
ClinVar: 10808
TCGA: ENSG00000120694
COSMIC: HSPH1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120694	ENST00000320027	Q92598
ENSG00000120694	ENST00000320027	A0A024RDS1
ENSG00000120694	ENST00000380405	Q92598
ENSG00000120694	ENST00000380405	A0A024RDQ0
ENSG00000120694	ENST00000435381	Q5TBM3
ENSG00000120694	ENST00000445273	A0A0A0MSM0
ENSG00000120694	ENST00000602786	R4GN69
ENSG00000120694	ENST00000630972	Q92598

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Binding and Uptake of Ligands by Scavenger Receptors	REACTOME	R-HSA-2173782
Scavenging by Class F Receptors	REACTOME	R-HSA-3000484
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to heat stress	REACTOME	R-HSA-3371556
Regulation of HSF1-mediated heat shock response	REACTOME	R-HSA-3371453

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38165608	2024	Extracellular vesicles related gene HSPH1 exerts anti-tumor effects in prostate cancer via promoting the stress response of CD8 + T cells.	1
38165608	2024	Extracellular vesicles related gene HSPH1 exerts anti-tumor effects in prostate cancer via promoting the stress response of CD8 + T cells.	1
34617313	2021	Functional differences between Hsp105/110 family proteins in cell proliferation, cell division, and drug sensitivity.	3
34618840	2021	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.	0
34617313	2021	Functional differences between Hsp105/110 family proteins in cell proliferation, cell division, and drug sensitivity.	3
34618840	2021	HSP105 expression in cutaneous malignant melanoma: Correlation with clinicopathological characteristics.	0
32128880	2020	HSP105 expression in oral squamous cell carcinoma: Correlation with clinicopathological features and outcomes.	3
32815538	2020	Oncogene HSPH1 modulated by the rs2280059 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.	8
32128880	2020	HSP105 expression in oral squamous cell carcinoma: Correlation with clinicopathological features and outcomes.	3
32815538	2020	Oncogene HSPH1 modulated by the rs2280059 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.	8
30496702	2019	Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint.	6
30542121	2019	HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells.	15
30496702	2019	Heat shock-induced mitotic arrest requires heat shock protein 105 for the activation of spindle assembly checkpoint.	6
30542121	2019	HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells.	15
29871863	2018	HSP110 sustains chronic NF-κB signaling in activated B-cell diffuse large B-cell lymphoma through MyD88 stabilization.	20

Citation

Takumi Hatayama ; Nobuyuki Yamagishi

HSPH1 (heat shock 105kDa/110kDa protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/40891/css/lib/hgnc