TCEA1 (transcription elongation factor A1)

2004-05-01  

Identity

HGNC
TCEA1
LOCATION
8q11.23
LOCUSID
6917
ALIAS
GTF2S,SII,TCEA,TF2S,TFIIS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6917
MIM: 601425
HGNC: 11612
Ensembl: ENSG00000187735

Variants:

dbSNP: 6917
ClinVar: 6917
TCGA: ENSG00000187735
COSMIC: TCEA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187735ENST00000396401P23193
ENSG00000187735ENST00000518310E5RFI1
ENSG00000187735ENST00000518784E5RJ93
ENSG00000187735ENST00000519704E5RK46
ENSG00000187735ENST00000520534E5RIS7
ENSG00000187735ENST00000521604P23193
ENSG00000187735ENST00000521604A0A384MTX4
ENSG00000187735ENST00000522635B7Z4S1
ENSG00000187735ENST00000638322A0A1W2PS15
ENSG00000187735ENST00000640041A0A1W2PRL9
ENSG00000187735ENST00000640382A0A1W2PPZ5
ENSG00000187735ENST00000640873A0A1W2PPV7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387879532024Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS.1
387879532024Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS.1
348222922021A ubiquitous disordered protein interaction module orchestrates transcription elongation.19
348222922021A ubiquitous disordered protein interaction module orchestrates transcription elongation.19
315195222019Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.56
315195222019Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.56
210707922011RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair.4
215963122011RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.59
210707922011RNA interference against transcription elongation factor SII does not support its role in transcription-coupled nucleotide excision repair.4
215963122011RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression.59
207291542010Transcription factor IIS impacts UV-inhibited transcription.13
207291542010Transcription factor IIS impacts UV-inhibited transcription.13
166308162006Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.54
167365002006CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas.27
166308162006Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.54

Citation

Dessen P

TCEA1 (transcription elongation factor A1)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/409/gene-fusions-explorer/img/favicon/haematological-explorer/