IFNB1 (interferon beta 1)

2003-08-01 Affiliation

Identity

HGNC

IFNB1

LOCATION

9p21.3

LOCUSID

3456

ALIAS

IFB,IFF,IFN-beta,IFNB

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3456
MIM: 147640
HGNC: 5434
Ensembl: ENSG00000171855

Variants:

dbSNP: 3456
ClinVar: 3456
TCGA: ENSG00000171855
COSMIC: IFNB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000171855	ENST00000380232	P01574

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Toll-like receptor signaling pathway	KEGG	ko04620
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Toll-like receptor signaling pathway	KEGG	hsa04620
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Hepatitis B	KEGG	hsa05161
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF3-dependent IRF activation pathway	REACTOME	R-HSA-918233
TRAF6 mediated IRF7 activation	REACTOME	R-HSA-933541
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733
Regulation of IFNA signaling	REACTOME	R-HSA-912694
Hemostasis	REACTOME	R-HSA-109582
Factors involved in megakaryocyte development and platelet production	REACTOME	R-HSA-983231
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37971173	2024	Human lung vascular endothelium may limit infection with HRV16 via IFN-β-dependent mechanisms.	0
37971173	2024	Human lung vascular endothelium may limit infection with HRV16 via IFN-β-dependent mechanisms.	0
36451263	2023	Early plasma interferon-β levels as a predictive marker of COVID-19 severe clinical events in adult patients.	5
36508750	2023	Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis.	7
36651716	2023	The double-stranded RNA-dependent protein kinase PKR negatively regulates the protein expression of IFN-β induced by RIG-I signaling.	2
36861386	2023	Pellino3 ligase negatively regulates influenza B dependent RIG-I signalling through downregulation of TRAF3-mediated induction of the transcription factor IRF3 and IFNβ production.	1
37011812	2023	Endoplasmic reticulum stress response and the regulation of endometrial interferon-beta production.	0
37068442	2023	IFN-β activates cytotoxic function of human natural killer cells toward IL-27 and poly(I:C) stimulated PC3 and DU145 cells.	0
37099383	2023	Hypoxia and acidity regulate immune checkpoint molecule and IFN-β expression in non-small cell lung cancer cell lines.	0
37847581	2023	Coxsackievirus A6 2C protein antagonizes IFN-β production through MDA5 and RIG-I depletion.	2
38067135	2023	C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.	0
38203523	2023	FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.	0
36451263	2023	Early plasma interferon-β levels as a predictive marker of COVID-19 severe clinical events in adult patients.	5
36508750	2023	Synergism of TNF-α and IFN-β triggers human airway epithelial cells death by apoptosis and pyroptosis.	7
36651716	2023	The double-stranded RNA-dependent protein kinase PKR negatively regulates the protein expression of IFN-β induced by RIG-I signaling.	2

Citation

Dessen P

IFNB1 (interferon beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40924/deep-insight-explorer/js/humanGenome