IGFBP2 (insulin like growth factor binding protein 2)

2003-08-01  

Identity

HGNC
IGFBP2
LOCATION
2q35
LOCUSID
3485
ALIAS
IBP2,IGF-BP53
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3485
MIM: 146731
HGNC: 5471
Ensembl: ENSG00000115457

Variants:

dbSNP: 3485
ClinVar: 3485
TCGA: ENSG00000115457
COSMIC: IGFBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115457ENST00000233809P18065
ENSG00000115457ENST00000434997C9JW52
ENSG00000115457ENST00000436812H7C1H0
ENSG00000115457ENST00000456764C9JMY1

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

References

Pubmed IDYearTitleCitations
379821732024Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.0
379922952024Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.1
383164222024Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.1
384905052024Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.1
385060342024The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.0
387291522024A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.0
389183602024IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.0
379821732024Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.0
379922952024Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.1
383164222024Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.1
384905052024Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.1
385060342024The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.0
387291522024A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.0
389183602024IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.0
367877362023Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.12

Citation

Dessen P

IGFBP2 (insulin like growth factor binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40931/haematological-explorer/css/haematological-explorer/