IGFBP2 (insulin like growth factor binding protein 2)

2003-08-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
IBP2,IGF-BP53
FUSION GENES

Other Information

Locus ID:

NCBI: 3485
MIM: 146731
HGNC: 5471
Ensembl: ENSG00000115457

Variants:

dbSNP: 3485
ClinVar: 3485
TCGA: ENSG00000115457
COSMIC: IGFBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115457ENST00000233809P18065
ENSG00000115457ENST00000434997C9JW52
ENSG00000115457ENST00000436812H7C1H0
ENSG00000115457ENST00000456764C9JMY1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

References

Pubmed IDYearTitleCitations
379821732024Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.0
379922952024Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.1
383164222024Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.1
384905052024Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.1
385060342024The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.0
387291522024A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.0
389183602024IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.0
379821732024Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.0
379922952024Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.1
383164222024Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.1
384905052024Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.1
385060342024The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.0
387291522024A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.0
389183602024IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.0
367877362023Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.12

Citation

Dessen P

IGFBP2 (insulin like growth factor binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40931/tumors-explorer/cancer-prone-explorer/favicon/manifest.json