IL10 (interleukin 10)

2003-08-01  

Identity

HGNC
IL10
LOCATION
1q32.1
LOCUSID
3586
ALIAS
CSIF,GVHDS,IL-10,IL10A,TGIF

Other Information

Locus ID:

NCBI: 3586
MIM: 124092
HGNC: 5962
Ensembl: ENSG00000136634

Variants:

dbSNP: 3586
ClinVar: 3586
TCGA: ENSG00000136634
COSMIC: IL10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136634ENST00000423557P22301
ENSG00000136634ENST00000423557Q6FGW4
ENSG00000136634ENST00000471071A0A286YEX3
ENSG00000136634ENST00000659065A0A590UK12
ENSG00000136634ENST00000659642A0A590UK12
ENSG00000136634ENST00000664374A0A590UK12

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
T cell receptor signaling pathwayKEGGko04660
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
T cell receptor signaling pathwayKEGGhsa04660
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
FoxO signaling pathwayKEGGhsa04068
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134850491TransplantationDiseaseClinicalAnnotationassociatedPK
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociatedPD28750137
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD18444945, 22094953
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPD24819158
PA447247liver transplantationDiseaseClinicalAnnotationassociatedPD21359536
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD18444945
PA449441efavirenzChemicalClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD24819158
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD18444945
PA451261rituximabChemicalMultilinkAnnotationassociated26384320
PA451365sirolimusChemicalClinicalAnnotationassociatedPK22094953
PA451578tacrolimusChemicalClinicalAnnotationassociatedPKPD21359536

References

Pubmed IDYearTitleCitations
370947952024Interleukin 10, but not tumor necrosis factor-alpha, gene variations are associated with factor VII inhibitor development.0
378429942024IL-6, IL-10 and TNF-α gene polymorphisms in preeclampsia: a case-control study in a Mexican population.0
379230012024The association of cytokines genes (IL-6 and IL-10) with the susceptibility to schizophrenia: A systematic review and meta-analysis.1
379514182024Interleukin 10 (IL10) promoter region polymorphism is associated with IL10 serum concentrations and processing speed in healthy community-dwelling older adults.0
379534012024Association of IL-23R and IL-10 variations with Behçet disease: a genetic analysis study.0
379554082024Interleukin-10 promoter polymorphisms and haplotypes in patients with Guillain-Barré syndrome.0
381695992024Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury.1
382632892024An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life.0
382799972024The complex role of IL-10 in malignant ascites: a review.0
382857962024Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk.1
382862702024Cytokines signatures and susceptibility to cutaneous leishmaniasis in patients from Sistan and Baluchestan province of Iran.0
382873622024Association of IL-10-592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes.1
383655752024The pertinence of gastric cancer and interleukin 10-819 single nucleotide polymorphisms: a meta-analysis and systematic review.0
384000502024Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors.0
384155312024Interleukin-6 And Interleukin-10 Polymorphisms In Chronic Lymphoid Leukemia Patients.0

Citation

Dessen P

IL10 (interleukin 10)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40939/css/lib/favicon/deep-insight-explorer/