IL12A (interleukin 12A)

2003-08-01 Affiliation

Identity

HGNC

IL12A

LOCATION

3q25.33

LOCUSID

3592

ALIAS

CLMF,IL-12A,NFSK,NKSF1,P35

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3592
MIM: 161560
HGNC: 5969
Ensembl: ENSG00000168811

Variants:

dbSNP: 3592
ClinVar: 3592
TCGA: ENSG00000168811
COSMIC: IL12A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168811	ENST00000305579	P29459
ENSG00000168811	ENST00000305579	O60595
ENSG00000168811	ENST00000466512	E9PGR3
ENSG00000168811	ENST00000480787	E7ENE1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Toll-like receptor signaling pathway	KEGG	ko04620
Jak-STAT signaling pathway	KEGG	ko04630
Type I diabetes mellitus	KEGG	ko04940
Allograft rejection	KEGG	ko05330
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Toll-like receptor signaling pathway	KEGG	hsa04620
Jak-STAT signaling pathway	KEGG	hsa04630
Type I diabetes mellitus	KEGG	hsa04940
Allograft rejection	KEGG	hsa05330
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Amoebiasis	KEGG	ko05146
Amoebiasis	KEGG	hsa05146
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
African trypanosomiasis	KEGG	ko05143
African trypanosomiasis	KEGG	hsa05143
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-6 family signaling	REACTOME	R-HSA-6783589
IL-6-type cytokine receptor ligand interactions	REACTOME	R-HSA-6788467
Interleukin-12 signaling	REACTOME	R-HSA-447115
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807
Interleukin-10 signaling	REACTOME	R-HSA-6783783

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated	PD	21107304
PA166048654	ustekinumab	Chemical	LabelAnnotation	associated
PA450566	mycophenolate mofetil	Chemical	ClinicalAnnotation	associated	PD	21107304

References

Pubmed ID	Year	Title	Citations
38278031	2024	Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes.	1
38690286	2024	The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.	0
38278031	2024	Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes.	1
38690286	2024	The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis.	0
35959714	2023	Immunomodulatory effect of IL-35 gene-transfected mesenchymal stem cells on allergic asthma.	4
37195820	2023	A Meta-Analysis of the Association Between Genetic Polymorphisms in IL-12, IL-17, and IL-21 and Risk of Hepatitis B Virus Infection.	0
37326977	2023	IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis.	1
37878703	2023	Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.	2
38203575	2023	Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.	1
35959714	2023	Immunomodulatory effect of IL-35 gene-transfected mesenchymal stem cells on allergic asthma.	4
37195820	2023	A Meta-Analysis of the Association Between Genetic Polymorphisms in IL-12, IL-17, and IL-21 and Risk of Hepatitis B Virus Infection.	0
37326977	2023	IL-8 and IL-12p70 are associated with pelvic pain among infertile women with endometriosis.	1
37878703	2023	Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.	2
38203575	2023	Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis.	1
33878182	2022	Altered CD4+ T cell and cytokine levels in peripheral blood and skin samples from systemic sclerosis patients and IL-35 in CD4+ T cell growth.	8

Citation

Dessen P

IL12A (interleukin 12A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40940/deep-insight-explorer/js/lib/cancer-prone-explorer/