IL24 (interleukin 24)

2003-02-01  

Identity

HGNC
IL24
LOCATION
1q32.1
LOCUSID
11009
ALIAS
C49A,FISP,IL10B,MDA7,MOB5,ST16

Other Information

Locus ID:

NCBI: 11009
MIM: 604136
HGNC: 11346
Ensembl: ENSG00000162892

Variants:

dbSNP: 11009
ClinVar: 11009
TCGA: ENSG00000162892
COSMIC: IL24

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162892ENST00000294984Q13007
ENSG00000162892ENST00000367093Q13007
ENSG00000162892ENST00000367095E7ER64
ENSG00000162892ENST00000391929Q13007
ENSG00000162892ENST00000480741E7ETP6
ENSG00000162892ENST00000611909Q13007

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
389053842024Serum level of interleukin-24 and its polymorphism in eczematic Iraqi patients.0
389053842024Serum level of interleukin-24 and its polymorphism in eczematic Iraqi patients.0
371651702023Hypoxia and IL-24 drive a sterile wound healing pathway.2
371651702023Hypoxia and IL-24 drive a sterile wound healing pathway.2
350992972022Interleukin-24 Limits Tumor-Infiltrating T Helper 17 Cell Response in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma.3
351482012022Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.19
350992972022Interleukin-24 Limits Tumor-Infiltrating T Helper 17 Cell Response in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma.3
351482012022Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.19
325619122021IL-10 and Its Related Superfamily Members IL-19 and IL-24 Provide Parallel/Redundant Immune-Modulation in Loa loa Infection.4
330520622021LINC00511-dependent inhibition of IL-24 contributes to the oncogenic role of HNF4α in colorectal cancer.6
331446782021IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages.41
333589012021RNA binding protein GNL3 up-regulates IL24 and PTN to promote the development of osteoarthritis.7
334415382021IL-24 armored CAR19-T cells show enhanced antitumor activity and persistence.4
335340282021Role of IL-24 in NK cell activation and its clinical implication in systemic lupus erythematosus.3
335598582021Interleukin (IL)-24: Reconfiguring the Tumor Microenvironment for Eliciting Antitumor Response.1

Citation

Dessen P

IL24 (interleukin 24)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40956/haematological-explorer/gene-explorer/gene-explorer/