IL4 (interleukin 4)

2003-11-01  

Identity

HGNC
IL4
LOCATION
5q31.1
LOCUSID
3565
ALIAS
BCGF-1,BCGF1,BSF-1,BSF1,IL-4

Other Information

Locus ID:

NCBI: 3565
MIM: 147780
HGNC: 6014
Ensembl: ENSG00000113520

Variants:

dbSNP: 3565
ClinVar: 3565
TCGA: ENSG00000113520
COSMIC: IL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113520ENST00000231449P05112
ENSG00000113520ENST00000231449D4HNR6
ENSG00000113520ENST00000350025P05112
ENSG00000113520ENST00000350025Q5FC01
ENSG00000113520ENST00000622422U3LVN1

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Allograft rejectionKEGGko05330
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Allograft rejectionKEGGhsa05330
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
MeaslesKEGGko05162
MeaslesKEGGhsa05162
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD20921925
PA448497aspirinChemicalClinicalAnnotationassociatedPD20921925

References

Pubmed IDYearTitleCitations
378034932024Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR variants with FMF-related amyloidosis in a Turkish cohort.0
380576622024An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.11
381350092024IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.1
381461412024Interleukin-4 and Interleukin-17 are associated with coronary artery disease.1
381471252024IL-4-secreting CD40L(+) MAIT cells support antibody production in the peripheral blood of Heonch-Schönlein purpura patients.0
381550712024Expression of miR-21 &IL-4 in endometriosis.0
382067662024Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance.1
382385142024Evaluation of serum interleukin-12 and interleukin-4 as potential biomarkers for the diagnosis of major depressive disorder.1
384973432024The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months.0
386493532024PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus.0
386908182024Association of IL-4 polymorphism with severe periodontitis in a sample of Iraqi population.0
378034932024Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR variants with FMF-related amyloidosis in a Turkish cohort.0
380576622024An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.11
381350092024IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.1
381461412024Interleukin-4 and Interleukin-17 are associated with coronary artery disease.1

Citation

Dessen P

IL4 (interleukin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40960/js/meetings/gene-explorer/