IMPA1 (inositol monophosphatase 1)

2003-05-01  

Identity

HGNC
IMPA1
LOCATION
8q21.13
LOCUSID
3612
ALIAS
IMP,IMPA,MRT59
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3612
MIM: 602064
HGNC: 6050
Ensembl: ENSG00000133731

Variants:

dbSNP: 3612
ClinVar: 3612
TCGA: ENSG00000133731
COSMIC: IMPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133731ENST00000256108P29218
ENSG00000133731ENST00000256108A0A024R830
ENSG00000133731ENST00000311489P29218
ENSG00000133731ENST00000449740P29218
ENSG00000133731ENST00000449740A0A140VJL8
ENSG00000133731ENST00000518188E5RG94
ENSG00000133731ENST00000518202E5RI82
ENSG00000133731ENST00000519816E5RHE9
ENSG00000133731ENST00000519964E5RIP7
ENSG00000133731ENST00000521360E5RG13
ENSG00000133731ENST00000521979E5RIF4
ENSG00000133731ENST00000522997E5RGY4
ENSG00000133731ENST00000523942H0YBL1

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGhsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGM00131
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP2, IP, and Ins in the cytosolREACTOMER-HSA-1855183

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
357966462023Inositol monophosphatase 1 (IMPA1) promotes triple-negative breast cancer progression through regulating mTOR pathway and EMT process.2
357966462023Inositol monophosphatase 1 (IMPA1) promotes triple-negative breast cancer progression through regulating mTOR pathway and EMT process.2
328395132021Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis.4
328395132021Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis.4
306166292019Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG.5
306166292019Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG.5
302894072018Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.2
302894072018Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.2
264165442016A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.12
274404382016Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.7
264165442016A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability.12
274404382016Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme.7
230277372012Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.5
230277372012Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.5
201533842010Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.8

Citation

Dessen P

IMPA1 (inositol monophosphatase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40971/css/gene-fusions-explorer/welcome