IMPDH2 (inosine monophosphate dehydrogenase 2)

2003-08-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
IMPD2,IMPDH-II
FUSION GENES

Other Information

Locus ID:

NCBI: 3615
MIM: 146691
HGNC: 6053
Ensembl: ENSG00000178035

Variants:

dbSNP: 3615
ClinVar: 3615
TCGA: ENSG00000178035
COSMIC: IMPDH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178035ENST00000326739P12268
ENSG00000178035ENST00000326739A0A384N6C2
ENSG00000178035ENST00000429182H0Y4R1
ENSG00000178035ENST00000442157E7ETK5

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Drug metabolism - other enzymesKEGGko00983
Purine metabolismKEGGhsa00230
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine ribonucleoside monophosphate biosynthesisREACTOMER-HSA-73817
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalClinicalAnnotation, PathwayassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765, 24220207
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 21996196, 22960765
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765

References

Pubmed IDYearTitleCitations
383102292024Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.0
383102292024Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.0
366290542023c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.6
366485202023Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population.1
366572792023Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia.0
374141522023Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.1
379070472023Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway.1
366290542023c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.6
366485202023Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population.1
366572792023Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia.0
374141522023Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.1
379070472023Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway.1
346731272022Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.9
354848842022Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation.0
361770322022SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling.6

Citation

Dessen P

IMPDH2 (inosine monophosphate dehydrogenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40972/css/haematological-explorer/favicon/manifest.json