IMPDH2 (inosine monophosphate dehydrogenase 2)

2003-08-01  

Identity

HGNC
IMPDH2
LOCATION
3p21.31
LOCUSID
3615
ALIAS
IMPD2,IMPDH-II
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3615
MIM: 146691
HGNC: 6053
Ensembl: ENSG00000178035

Variants:

dbSNP: 3615
ClinVar: 3615
TCGA: ENSG00000178035
COSMIC: IMPDH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178035ENST00000326739P12268
ENSG00000178035ENST00000326739A0A384N6C2
ENSG00000178035ENST00000429182H0Y4R1
ENSG00000178035ENST00000442157E7ETK5

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Drug metabolism - other enzymesKEGGko00983
Purine metabolismKEGGhsa00230
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Purine metabolismREACTOMER-HSA-73847
Purine ribonucleoside monophosphate biosynthesisREACTOMER-HSA-73817
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalClinicalAnnotation, PathwayassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765, 24220207
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 21996196, 22960765
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPD18444945, 19617864, 19770842, 20679962, 21996196, 22960765

References

Pubmed IDYearTitleCitations
383102292024Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.0
383102292024Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.0
366290542023c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.6
366485202023Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population.1
366572792023Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia.0
374141522023Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.1
379070472023Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway.1
366290542023c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.6
366485202023Rare variants in IMPDH2 cause autosomal dominant dystonia in Chinese population.1
366572792023Genetic analysis of IMPDH2 gene in Taiwanese patients with isolated or combined dystonia.0
374141522023Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation.1
379070472023Single-cell RNA sequencing in double-hit lymphoma: IMPDH2 induces the progression of lymphoma by activating the PI3K/AKT/mTOR signaling pathway.1
346731272022Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.9
354848842022Silencing of hepsin and inosine 5-monophosphate dehydrogenase 2 by siRNA reduces prostate cancer cells proliferation.0
361770322022SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling.6

Citation

Dessen P

IMPDH2 (inosine monophosphate dehydrogenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40972/css/haematological-explorer/favicon/manifest.json