ITGB2 (integrin subunit beta 2)

2003-05-01  

Identity

HGNC
ITGB2
LOCATION
21q22.3
LOCUSID
3689
ALIAS
CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3689
MIM: 600065
HGNC: 6155
Ensembl: ENSG00000160255

Variants:

dbSNP: 3689
ClinVar: 3689
TCGA: ENSG00000160255
COSMIC: ITGB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160255ENST00000302347P05107
ENSG00000160255ENST00000320216J3KNI6
ENSG00000160255ENST00000355153P05107
ENSG00000160255ENST00000397846A8MVG7
ENSG00000160255ENST00000397850P05107
ENSG00000160255ENST00000397852P05107
ENSG00000160255ENST00000397854D3DSM0
ENSG00000160255ENST00000397857P05107
ENSG00000160255ENST00000517563E5RIG7
ENSG00000160255ENST00000517819E5RFI0
ENSG00000160255ENST00000520389E5RIE4
ENSG00000160255ENST00000521995E5RHT0
ENSG00000160255ENST00000522688E5RK54
ENSG00000160255ENST00000522931E5RK25
ENSG00000160255ENST00000523323E5RGK9
ENSG00000160255ENST00000523663E7EVZ9
ENSG00000160255ENST00000524251E5RHE6
ENSG00000160255ENST00000652462A0A494C0X7

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Complement and coagulation cascadesKEGGko04610
Natural killer cell mediated cytotoxicityKEGGko04650
Leukocyte transendothelial migrationKEGGko04670
Regulation of actin cytoskeletonKEGGko04810
Cell adhesion molecules (CAMs)KEGGhsa04514
Complement and coagulation cascadesKEGGhsa04610
Natural killer cell mediated cytotoxicityKEGGhsa04650
Leukocyte transendothelial migrationKEGGhsa04670
Regulation of actin cytoskeletonKEGGhsa04810
Viral myocarditisKEGGhsa05416
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
MalariaKEGGko05144
MalariaKEGGhsa05144
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Extracellular matrix organizationREACTOMER-HSA-1474244
Integrin cell surface interactionsREACTOMER-HSA-216083
Neutrophil degranulationREACTOMER-HSA-6798695
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379231032024Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.1
379375212024Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.0
381501542024ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.3
379231032024Identification of an association between coronary heart disease and ITGB2 methylation in peripheral blood by a case-control study.1
379375212024Decreased toll-like receptor 4 and CD11b/CD18 expression on peripheral monocytes of hypertensive patients correlates with a lesser extent of endothelial damage: a preliminary study.0
381501542024ITGB2-ICAM1 axis promotes liver metastasis in BAP1-mutated uveal melanoma with retained hypoxia and ECM signatures.3
372507172023Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.3
373714732023Targeting Neutrophil β(2)-Integrins: A Review of Relevant Resources, Tools, and Methods.5
376445372023Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.0
376605692023Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types.3
378921702023Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.0
372507172023Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic candidate genes for diabetic nephropathy using bioinformatics analysis.3
373714732023Targeting Neutrophil β(2)-Integrins: A Review of Relevant Resources, Tools, and Methods.5
376445372023Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.0
376605692023Characterization of tumor microenvironment in glioblastoma multiforme identifies ITGB2 as a key immune and stromal related regulator in glial cell types.3

Citation

Dessen P

ITGB2 (integrin subunit beta 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41018/js/lib/favicon/deep-insight-explorer/