KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1)

2003-08-01  

Identity

HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
BKbeta1,K(VCA)beta,SLO-BETA,hbeta1,hslo-beta,k(VCA)beta-1,slo-beta-1
FUSION GENES

Other Information

Locus ID:

NCBI: 3779
MIM: 603951
HGNC: 6285
Ensembl: ENSG00000145936

Variants:

dbSNP: 3779
ClinVar: 3779
TCGA: ENSG00000145936
COSMIC: KCNMB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145936ENST00000274629Q16558
ENSG00000145936ENST00000521859Q16558

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Insulin secretionKEGGhsa04911
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Ca2+ activated K+ channelsREACTOMER-HSA-1296052
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD17700361
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD17700361, 18496125, 18854753
PA451868verapamilChemicalClinicalAnnotationassociatedPD17700361, 18496125, 18854753

References

Pubmed IDYearTitleCitations
314866692020The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.18
314866692020The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis.18
298507922019Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients.10
298507922019Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients.10
284296152017Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling.13
287500982017The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits.2
284296152017Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling.13
287500982017The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits.2
272175762016β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.9
272175762016β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel.9
2557687120157-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.1
258257132015Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels.15
2557687120157-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels.1
258257132015Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels.15
244767612014Bisphenol A activates BK channels through effects on α and β1 subunits.5

Citation

Dessen P

KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41050/haematological-explorer/meetings/