KISS1 (KiSS-1 metastasis suppressor)

2003-02-01  

Identity

HGNC
KISS1
LOCATION
1q32.1
LOCUSID
3814
ALIAS
HH13,KiSS-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3814
MIM: 603286
HGNC: 6341
Ensembl: ENSG00000170498

Variants:

dbSNP: 3814
ClinVar: 3814
TCGA: ENSG00000170498
COSMIC: KISS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170498ENST00000367194Q15726
ENSG00000170498ENST00000625357A0A0D9SES6

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
223357402012Inactivating KISS1 mutation and hypogonadotropic hypogonadism.119
174887992007Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys.102
184345212008Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels.90
202371662010Mutations of the KISS1 gene in disorders of puberty.67
202371662010Mutations of the KISS1 gene in disorders of puberty.67
205291192010The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
125742332003Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans.55
208584642010Anatomy of the kisspeptin neural network in mammals.48
155926842005Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases.46

Citation

Dessen P

KISS1 (KiSS-1 metastasis suppressor)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41072/kiss1-(kiss-1-metastasis-suppressor)