LAMC3 (laminin subunit gamma 3)

2003-06-01  

Identity

HGNC
LAMC3
LOCATION
9q34.12
LOCUSID
10319
ALIAS
OCCM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10319
MIM: 604349
HGNC: 6494
Ensembl: ENSG00000050555

Variants:

dbSNP: 10319
ClinVar: 10319
TCGA: ENSG00000050555
COSMIC: LAMC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000050555ENST00000355452H7BY04
ENSG00000050555ENST00000361069Q9Y6N6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343044412021[Relationships between decreased LAMC3 and poor prognosis in ovarian cancer].3
343044412021[Relationships between decreased LAMC3 and poor prognosis in ovarian cancer].3
296266092019Homozygous LAMC3 mutation links to structural and functional changes in visual attention networks.5
296266092019Homozygous LAMC3 mutation links to structural and functional changes in visual attention networks.5
292473752018A novel mutation in LAMC3 associated with generalized polymicrogyria of the cortex and epilepsy.6
297952812018Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation.16
292473752018A novel mutation in LAMC3 associated with generalized polymicrogyria of the cortex and epilepsy.6
297952812018Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation.16
277498452016Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.109
277498452016Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.109
263946012015Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.8
263946012015Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.8
229617622013β2 and γ3 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia.37
229617622013β2 and γ3 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia.37
215724132011Recessive LAMC3 mutations cause malformations of occipital cortical development.52

Citation

Dessen P

LAMC3 (laminin subunit gamma 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41120/meetings/css/lib/deep-insight-explorer/